Reactive oxygen species (ROS) potentially affected survival rate after ionizing radiation in scallops
文献类型：期刊论文
| 作者 | Zhang, Zebin2; Wang, Rui2; Lin, Jieshan2; Gong, Zhiqian2; Cao, Haowen2; Wang, Chunde1,2; Lu, Xia2 |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2026-02-01 |
| 卷号 | 169页码:10 |
| 关键词 | Peroxisome Autophagy Ionizing radiation Scallops |
| ISSN号 | 1050-4648 |
| DOI | 10.1016/j.fsi.2025.111093 |
| 通讯作者 | Wang, Chunde(Chundewang2007@163.com) ; Lu, Xia(luxia_0202@163.com) |
| 英文摘要 | Ionizing radiation (IR) accelerates aging and increases the risk of death in organisms. The two scallops, Argopecten purpuratus (7-10 years) and A. irradians (less than 14 months), have markedly different lifespans and exhibited different tolerance to IR. However, little information was available for understanding why the A. purpuratus had a higher survival rate after IR. In the present study, we first investigated genetic responses to IR in the two scallops by comparative transcriptome analysis. After IR exposure, the A. purpuratus has more significantly up-regulated expressed genes (mainly involved in neuroactive ligand-receptor interaction, peroxisome, autophagy, and DNA repair), but the A. irradians has more significantly down-regulated expressed genes (mainly involved in lysosome, peroxisome, autophagy, DNA repair, and apoptosis). In addition, the main genes and pathways that respond to IR are completely different between the two scallops. The expression of ATG5, BAX, CTSL, CTSB, ULK2, and ATG9A, which are important genes for autophagy, was significantly downregulated in the A. irradians, which may contribute to its early mortality. However, the expression of SOD1, CAT, SCD, and ACOX1, which perform the function of antioxidation, significantly increased in the A. purpuratus, potentially mitigating ROS-induced cellular damage. In addition, the ROS level in the A. purpuratus was significantly lower than the A. irradians after IR. These findings suggested that ROS potentially contribute to bivalve tolerance to IR, and also suggest potential biomarkers for breeding scallops with a high survival rate. |
| WOS关键词 | DNA-DAMAGE ; OXIDATIVE STRESS ; AUTOPHAGY ; LONGEVITY ; APOPTOSIS ; MUTATION ; LYSOSOME ; SIGNALS ; CYCLE |
| WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001656449000001 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/41995]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Wang, Chunde; Lu, Xia |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai 264003, Shandong, Peoples R China 2.Yantai Univ, Sch Ocean, Yantai 264005, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zebin,Wang, Rui,Lin, Jieshan,et al. Reactive oxygen species (ROS) potentially affected survival rate after ionizing radiation in scallops[J]. FISH & SHELLFISH IMMUNOLOGY,2026,169:10. |
| APA | Zhang, Zebin.,Wang, Rui.,Lin, Jieshan.,Gong, Zhiqian.,Cao, Haowen.,...&Lu, Xia.(2026).Reactive oxygen species (ROS) potentially affected survival rate after ionizing radiation in scallops.FISH & SHELLFISH IMMUNOLOGY,169,10. |
| MLA | Zhang, Zebin,et al."Reactive oxygen species (ROS) potentially affected survival rate after ionizing radiation in scallops".FISH & SHELLFISH IMMUNOLOGY 169(2026):10. |
入库方式： OAI收割
来源：烟台海岸带研究所
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