Identification and characterization of broad-spectrum cathelicidin family antimicrobial peptides from the pygmy sperm whale Kogia breviceps
文献类型：期刊论文
| 作者 | Zhang, Pingchuan1,4; Ye, Zifan1,2; Dou, Haoran1,3; Li, Shuangyu1,4; Jiao, Xudong1,4; Wang, Yipeng1,4 |
| 刊名 | BIOCHEMICAL PHARMACOLOGY
 |
| 出版日期 | 2026-03-01 |
| 卷号 | 245页码:22 |
| 关键词 | Antimicrobial peptides Cathelicidin Kogia breviceps Antibacterial activity |
| ISSN号 | 0006-2952 |
| DOI | 10.1016/j.bcp.2026.117675 |
| 通讯作者 | Jiao, Xudong(xdjiao@yic.ac.cn) ; Wang, Yipeng(ypwang@yic.ac.cn) |
| 英文摘要 | Cathelicidins are crucial antimicrobial peptides (AMPs) that play a key role in the innate immunity of marine vertebrates. The pygmy sperm whale (Kogia breviceps), which resides in environments populated by diverse microbial communities, faces complex pathogenic threats; however, its cathelicidin family AMPs remain uncharacterized. In this study, we identified three novel cathelicidin peptides-Kb4-1, Kb4-2, and Kb5 from the whale (Kogia breviceps). All three peptides exhibited broad-spectrum and potent antibacterial activity, with Kb5, an amphipathic alpha-helical peptide, showing the strongest and fastest bactericidal effect. Moreover, these peptides effectively inhibited biofilm formation, disrupted pre-established biofilms, and eradicated bacterial persister cells. Notably, Kb5 induced the most pronounced bacterial membrane disruption among the three peptides. Additionally, all peptides exerted their antibacterial effects, at least partially, through the interaction with bacterial DNA and the consequent induction of reactive oxygen species (ROS) production. In a S. aureus-induced murine peritonitis model, Kb5 treatment significantly reduced bacterial load and improved survival rates in mice. These findings highlight the therapeutic potential of Kb5 and enhance our understanding of host defense mechanisms in marine mammals living in challenging environments. |
| WOS关键词 | IN-VITRO ; CELLS ; RESISTANCE ; PATHOGENS ; GROWTH |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001663578200001 |
| 资助机构 | National Natural Science Foundation of China ; Key Research & Development Plan in Social Development of Jiangsu Province ; Shan-dong Technology-based SMEs Innovation Capability Enhancement Project ; Special Fund for the Scholar Program of Yantai |
| 源URL | [http://ir.yic.ac.cn/handle/133337/42029]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Jiao, Xudong; Wang, Yipeng |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Soochow Univ, Coll Pharmaceut Sci, Dept Biopharmaceut Sci, Suzhou 215123, Jiangsu, Peoples R China 3.Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Pingchuan,Ye, Zifan,Dou, Haoran,et al. Identification and characterization of broad-spectrum cathelicidin family antimicrobial peptides from the pygmy sperm whale Kogia breviceps[J]. BIOCHEMICAL PHARMACOLOGY,2026,245:22. |
| APA | Zhang, Pingchuan,Ye, Zifan,Dou, Haoran,Li, Shuangyu,Jiao, Xudong,&Wang, Yipeng.(2026).Identification and characterization of broad-spectrum cathelicidin family antimicrobial peptides from the pygmy sperm whale Kogia breviceps.BIOCHEMICAL PHARMACOLOGY,245,22. |
| MLA | Zhang, Pingchuan,et al."Identification and characterization of broad-spectrum cathelicidin family antimicrobial peptides from the pygmy sperm whale Kogia breviceps".BIOCHEMICAL PHARMACOLOGY 245(2026):22. |
入库方式： OAI收割
来源：烟台海岸带研究所
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