An Integrated NIR-II Fluorescence-Free Reporter for Multimodal Imaging-Guided Breast-Conserving Surgery
文献类型：期刊论文
| 作者 | Wang, Xinwei1; Shi, Kexin1; Wang, Ye1; Shao, Changli1; Li, Jin2 |
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2026-02-04 |
| 卷号 | 26期号:4页码:1201-1210 |
| 关键词 | Breast-conserving surgery Fluorescence-free reporter Tumor margin Multimodal imaging Second near-infrared |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.5c04589 |
| 通讯作者 | Shao, Changli(shaocl@jmsu.edu.cn) ; Li, Jin(jinli@yic.ac.cn) |
| 英文摘要 | Breast-conserving surgery is the most common treatment method for the treatment of breast tumors. However, achieving precise tumor margin delineation for improving surgical outcomes remains a foremost challenge. Here, we present a second near-infrared (NIR-II) fluorescence-free reporter (NiS8) that integrates magnetic resonance imaging (MRI)-photoacoustic imaging (PAI)-surface-enhanced resonant Raman scattering imaging. The nickel-containing NiS8 exhibits intense photon-resonant absorption but is nonemissive, facilitating the development of fluorescence-free trimodal nanoprobes (RPM nanoparticles) with improved Raman/PAI properties and signal correlation. Upon systemic administration of RPM nanoparticles, preoperative MRI first identifies the location, size, and shape of orthotopic breast tumors for surgical planning. Next, intraoperative Raman scanning enables high-accuracy delineation of tumor positive margins for step-by-step tumor removal in NIR-II, while intraoperative PAI simultaneously visualizes deep-seated residual lesions in the surgical cavity. Finally, postoperative Raman imaging allows for validating clean negative margins in the surgical bed, corroborated by histological staining, thus collectively verifying complete tumor resection. |
| WOS关键词 | SURFACE-ENHANCED RAMAN ; SPECTROSCOPY ; NANOPARTICLES ; COMPLEXES ; THERAPY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001667687600001 |
| 资助机构 | National Natural Science Foundation of China ; Center for Scientific Research and Development of Higher Education Institutions, Ministry of Education, Production, study and research projects |
| 源URL | [http://ir.yic.ac.cn/handle/133337/42053]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Shao, Changli; Li, Jin |
| 作者单位 | 1.Jiamusi Univ, Sch Basic Med, Dept Immunol, Jiamusi 154007, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xinwei,Shi, Kexin,Wang, Ye,et al. An Integrated NIR-II Fluorescence-Free Reporter for Multimodal Imaging-Guided Breast-Conserving Surgery[J]. NANO LETTERS,2026,26(4):1201-1210. |
| APA | Wang, Xinwei,Shi, Kexin,Wang, Ye,Shao, Changli,&Li, Jin.(2026).An Integrated NIR-II Fluorescence-Free Reporter for Multimodal Imaging-Guided Breast-Conserving Surgery.NANO LETTERS,26(4),1201-1210. |
| MLA | Wang, Xinwei,et al."An Integrated NIR-II Fluorescence-Free Reporter for Multimodal Imaging-Guided Breast-Conserving Surgery".NANO LETTERS 26.4(2026):1201-1210. |
入库方式： OAI收割
来源：烟台海岸带研究所
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