Micro/nanoplastics enhance multigenerational reproductive toxicity of legacy and alternative per-and polyfluoroalkyl substances in the marine rotifer Brachionus plicatilis
文献类型：期刊论文
| 作者 | Sun, Tao1; Wu, Huifeng1,2 |
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2026-04-15 |
| 卷号 | 395页码:8 |
| 关键词 | Micro/nanoplastics Per-and polyfluoroalkyl substances Multigenerational effects Life-history traits Marine zooplankton |
| ISSN号 | 0269-7491 |
| DOI | 10.1016/j.envpol.2026.127791 |
| 通讯作者 | Wu, Huifeng(hfwu@yic.ac.cn) |
| 英文摘要 | Micro/Nanoplastics (MNPs) and per- and polyfluoroalkyl substances (PFASs) are emerging environmental contaminants of global concern. This study assessed the acute and multigenerational toxicity of perfluorooctanoic acid (PFOA) and its alternative, hexafluoropropylene oxide dimer acid (HFPO-DA, also commercially known as GenX), in the marine rotifer Brachionus plicatilis, in the presence of 80 nm and 5 mu m MNPs. Acute toxicity tests demonstrated that MNPs enhanced the lethality and reproductive toxicity of both PFOA and GenX in a sizedependent manner. At the population level, MNPs exacerbated the inhibitory effects of these compounds on population growth. In multigenerational assays, fecundity was identified as the most sensitive life-history trait, exhibiting cumulative multigenerational impairments that were more pronounced in the presence of NPs. This trend aligned with the expression patterns of reproduction-related genes. Transcriptomic analysis further showed that co-exposure to NPs increased the number of differentially expressed genes, particularly those involved in metabolic and steroid biosynthesis pathways, suggesting elevated energy demands and reproductive toxicity. Collectively, these findings highlight the necessity of incorporating mixture toxicity and multigenerational effects into risk assessment frameworks to achieve more realistic chemical risk characterization and management. |
| WOS关键词 | MICROPLASTICS ; ENVIRONMENT ; EMISSIONS |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001690301900001 |
| 资助机构 | National Natural Science Foun-dation of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/42131]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Wu, Huifeng |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China 2.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Tao,Wu, Huifeng. Micro/nanoplastics enhance multigenerational reproductive toxicity of legacy and alternative per-and polyfluoroalkyl substances in the marine rotifer Brachionus plicatilis[J]. ENVIRONMENTAL POLLUTION,2026,395:8. |
| APA | Sun, Tao,&Wu, Huifeng.(2026).Micro/nanoplastics enhance multigenerational reproductive toxicity of legacy and alternative per-and polyfluoroalkyl substances in the marine rotifer Brachionus plicatilis.ENVIRONMENTAL POLLUTION,395,8. |
| MLA | Sun, Tao,et al."Micro/nanoplastics enhance multigenerational reproductive toxicity of legacy and alternative per-and polyfluoroalkyl substances in the marine rotifer Brachionus plicatilis".ENVIRONMENTAL POLLUTION 395(2026):8. |
入库方式： OAI收割
来源：烟台海岸带研究所
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