Metabolizable van der Waals enhanced Raman scattering probes for CXCR4-targeted imaging guided cancer therapy in NIR-II window
文献类型：期刊论文
| 作者 | Chen, Xinru1,2; Wang, Xiaoyan2; Li, Jin1 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2026-03-01 |
| 卷号 | 531页码:15 |
| 关键词 | Intermolecular vdW interactions Charge transfer enhanced Raman Second near-infrared Raman-guided surgery Postsurgical therapy Metabolizability |
| ISSN号 | 1385-8947 |
| DOI | 10.1016/j.cej.2026.174187 |
| 通讯作者 | Wang, Xiaoyan(wangxy@yic.ac.cn) ; Li, Jin(jinli@yic.ac.cn) |
| 英文摘要 | Raman spectroscopy in the second near-infrared (NIR-II, 1000-1700 nm) window has received ever-increasing attention in intraoperative tumor imaging due to its high specificity and penetration depth. However, the overwhelming majority of existing NIR-II Raman probes are fabricated by SERS with substrate enhancement, which raises serious biosafety concerns. Herein, we present van der Waals (vdW) enhanced Raman scattering (vdW-ERS) effect based on intermolecular charge transfer of dithiolene to develop ultrabright metal-free NIR-II Raman probes. The intermolecular charge transfer within dithiolene through vdW stacking is well illustrated by independent gradient model and ultrafast spectroscopy, which significantly boosts the intrinsic Raman properties with ultrahigh scattering cross-section (1.59 & times; 10-19 cm2) as well as the photothermal conversion efficacy (60.4%) through an additional femtosecond-scale non-radiative decay channel. Moreover, the fluorescence-free property of dithiolene greatly inhibits the spectral backgrounds and improves the photostability. In the tumor models of triple-negative breast cancer, vdW-ERS probes enable intraoperative CXCR4-targeted Raman-guided surgical resection and postoperative hyperthermia ablation of the residual microscopic tumors, resulting in approximately 100% survival rate. Importantly, vdW-ERS probes are hepatically excreted (ca. 92% excretion within two months), in stark contrast to accumulation in the liver for typical gold substrate-enhanced counterparts. Free from fluorescence background and photobleaching, intermolecular vdW-ERS effect presents a new mechanism for fabricating charge transfer Raman probes with the potential for clinical translation. |
| WOS关键词 | NANOPARTICLES |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001699558700001 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/42173]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Wang, Xiaoyan; Li, Jin |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Xinru,Wang, Xiaoyan,Li, Jin. Metabolizable van der Waals enhanced Raman scattering probes for CXCR4-targeted imaging guided cancer therapy in NIR-II window[J]. CHEMICAL ENGINEERING JOURNAL,2026,531:15. |
| APA | Chen, Xinru,Wang, Xiaoyan,&Li, Jin.(2026).Metabolizable van der Waals enhanced Raman scattering probes for CXCR4-targeted imaging guided cancer therapy in NIR-II window.CHEMICAL ENGINEERING JOURNAL,531,15. |
| MLA | Chen, Xinru,et al."Metabolizable van der Waals enhanced Raman scattering probes for CXCR4-targeted imaging guided cancer therapy in NIR-II window".CHEMICAL ENGINEERING JOURNAL 531(2026):15. |
入库方式： OAI收割
来源：烟台海岸带研究所
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