Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium
文献类型：期刊论文
| 作者 | Fu, Qiaomei3,4; Cao, Peng3; Dai, Qingyan3; Bennett, E. Andrew3; Feng, Xiaotian3; Yang, Melinda A.1; Ping, Wanjing3; Paabo, Svante5; Ji, Qiang2 |
| 刊名 | CELL
 |
| 出版日期 | 2025-07-24 |
| 卷号 | 188期号:15页码:3919-3926 |
| ISSN号 | 0092-8674 |
| DOI | 10.1016/j.cell.2025.05.040 |
| 英文摘要 | Denisovans have yet to be directly associated with a hominin cranium, limiting our understanding of their morphology and geographical distribution. We have attempted to retrieve DNA from a nearly complete Middle Pleistocene cranium from Harbin (>146 ka), northeastern China. Although no DNA could be retrieved from a tooth or the petrous bone, mitochondrial DNA (mtDNA) could be isolated from dental calculus. The mtDNA falls within Denisovan mtDNA variation and is related to an mtDNA branch carried by early Denisovan individuals in southern Siberia, previously observed in Denisova Cave. This suggests that Denisovans inhabited a large geographical range in Asia in the Middle Pleistocene. The association of Denisovan mtDNA with the Harbin cranium allows a better understanding of the morphological relationships between Denisovans and other East Asian Middle Pleistocene fossils. Furthermore, the retrieval of host DNA from dental calculus opens new possibilities for genetic research on Middle Pleistocene hominins. |
| WOS关键词 | GENOME SEQUENCE ; GENETIC HISTORY ; ANCIENT ; NEANDERTHAL ; CAVE ; HOMININ ; ENRICHMENT ; ASIA |
| 资助项目 | National Natural Science Foundation of China[41842039] ; Chinese Academy of Sciences of China (CAS)[YSBR-019] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001543361000002 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.205/handle/311034/24814]  |
| 专题 | 中国科学院古脊椎动物与古人类研究所 |
| 通讯作者 | Fu, Qiaomei |
| 作者单位 | 1.Univ Richmond, Dept Biol, Richmond, VA 23173 USA 2.Hebei GEO Univ, Coll Earth Sci, Hebei Int Joint Res Ctr Paleoanthropol, Shijiazhuang 050031, Peoples R China 3.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 4.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China 5.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany |
| 推荐引用方式 GB/T 7714 | Fu, Qiaomei,Cao, Peng,Dai, Qingyan,et al. Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium[J]. CELL,2025,188(15):3919-3926. |
| APA | Fu, Qiaomei.,Cao, Peng.,Dai, Qingyan.,Bennett, E. Andrew.,Feng, Xiaotian.,...&Ji, Qiang.(2025).Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium.CELL,188(15),3919-3926. |
| MLA | Fu, Qiaomei,et al."Denisovan mitochondrial DNA from dental calculus of the >146,000-year-old Harbin cranium".CELL 188.15(2025):3919-3926. |
入库方式： OAI收割
来源：古脊椎动物与古人类研究所
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