Impact of intermittent lead exposure on hominid brain evolution
文献类型：期刊论文
| 作者 | Joannes-Boyau, Renaud2,3,4; de Souza, Janaina Sena5; Arora, Manish6; Austin, Christine6; Westaway, Kira7; Moffat, Ian8,9; Wang, Wei10; Liao, Wei10; Zhang, Yingqi4; Adams, Justin W.3,11,12 |
| 刊名 | SCIENCE ADVANCES
 |
| 出版日期 | 2025-10-15 |
| 卷号 | 11期号:42页码:21 |
| DOI | 10.1126/sciadv.adr1524 |
| 英文摘要 | Gene-environmental interactions shape the evolution of brain architecture and function. Neuro-oncological ventral antigen 1 (NOVA1) is one gene that distinguishes modern humans from extinct hominids. However, the evolutionary pressures that selected the modern NOVA1 allele remain elusive. Here, we show using fossil teeth that several hominids (Australopithecus africanus, Paranthropus robustus, early Homo sp., Gigantopithecus blacki, Pongo sp., Homo neanderthalensis, and Homo sapiens) were consistently exposed to lead over 2 million years, contradicting the idea that lead exposure is solely a modern phenomenon. Moreover, lead exposure on human brain organoids carrying the archaic NOVA1 variant disrupts FOXP2 expression in cortical and thalamic organoids, a gene crucial for the development of human speech and language abilities. Overall, the fossil, cellular, and molecular data support that lead exposure may have contributed to the impact of social and behavioral functioning during evolution, likely affording modern humans a survival advantage. |
| WOS关键词 | HUMAN TOOTH ENAMEL ; U-SERIES ; GIGANTOPITHECUS-BLACKI ; BONE TURNOVER ; RNA-SEQ ; CHILDREN ; TEETH ; PLEISTOCENE ; EXPRESSION ; PREGNANCY |
| 资助项目 | Leakey Foundation ; UCSD Archaealization Center ; Neanderthal Brain Foundation ; National Institutes of Health[NIH R01MH100175] ; National Institutes of Health[NIH S10 OD026929] ; California Institute for Regenerative Medicine[DISC4-16377] ; US National Institute of Environmental Health Sciences[R01ES027981] ; Pontificia UniversidadeCatolica do Parana (PUCPR,Curitiba, Brazil) ; Australian Research Council Discovery Grants[DP170101597] ; Australian Research Council Discovery Grants[DP220100195] ; LIEF Grant[LE200100022] ; ARC Discovery Grant[DP230100440] ; ARC Future Fellowship[FT220100184] ; US National Institute of Environmental Health Sciences[P30ES023515] ; US National Institute of Environmental Health Sciences[R01ES026033] ; US National Institute of Environmental Health Sciences[U2CES030859] ; US National Institute of Environmental Health Sciences[U2CES026561] ; US National Institute of Environmental Health Sciences[R35ES030435] ; US National Institute of Environmental Health Sciences[UL1TR004419] ; Monash Interdisciplinary Research Seed Funding Scheme ; National Council for Scientific and Technological Development (CNPq)[311438/2022-9] ; National Council for Scientific and Technological Development (CNPq)[402773/2022-5] ; National Science Foundation (NSF)[BCS 0962564] ; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior ; Sao Paulo Research Foundation [FAPESP][2023/07144-0] ; Sao Paulo Research Foundation [FAPESP][2020/14158-9] ; Young Scientist Program at Hospital Sirio-Libanes |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001594864900001 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 源URL | [http://119.78.100.205/handle/311034/24887]  |
| 专题 | 中国科学院古脊椎动物与古人类研究所 |
| 通讯作者 | Joannes-Boyau, Renaud; Arora, Manish; Muotri, Alysson R. |
| 作者单位 | 1.UCSD, Sanford Consortium Regenerat Med, ISSCOR Integrated Space Stem Cell Orbital Res, La Jolla, CA 92093 USA 2.Southern Cross Univ, Geoarchaeol & Archaeometry Res Grp, Mil Rd, Lismore, NSW 2480, Australia 3.Univ Johannesburg, Palaeo Res Inst, Auckland Pk, ZA-2006 Johannesburg, South Africa 4.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 5.Univ Calif San Diego, Sch Med, Dept Pediat & Cellular & Mol Med, La Jolla, CA 92093 USA 6.Icahn Sch Med Mt Sinai, Dept Environm Med, New York, NY 10029 USA 7.Macquarie Univ, Fac Sci & Engn, Sch Nat Sci, Sydney, NSW 2109, Australia 8.Flinders Univ S Australia, Coll Humanities Arts & Social Sci, Archaeol, Adelaide, SA, Australia 9.Univ Cambridge, McDonald Inst Archaeol Res, Cambridge, England 10.Shandong Univ, Inst Cultural Heritage, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Joannes-Boyau, Renaud,de Souza, Janaina Sena,Arora, Manish,et al. Impact of intermittent lead exposure on hominid brain evolution[J]. SCIENCE ADVANCES,2025,11(42):21. |
| APA | Joannes-Boyau, Renaud.,de Souza, Janaina Sena.,Arora, Manish.,Austin, Christine.,Westaway, Kira.,...&Muotri, Alysson R..(2025).Impact of intermittent lead exposure on hominid brain evolution.SCIENCE ADVANCES,11(42),21. |
| MLA | Joannes-Boyau, Renaud,et al."Impact of intermittent lead exposure on hominid brain evolution".SCIENCE ADVANCES 11.42(2025):21. |
入库方式： OAI收割
来源：古脊椎动物与古人类研究所
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