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An early East Asian lineage with unexpectedly low Denisovan ancestry

文献类型：期刊论文

作者Yang, Jiaqi1; Iasi, Leonardo N. M.1; Fu, Qiaomei2; Kelso, Janet1; Cooke, Niall P.1; Peyregne, Stephane1; Peter, Benjamin M.1,2,3
刊名CURRENT BIOLOGY
出版日期2025-10-20
卷号35期号:20页码:4898-4908
ISSN号0960-9822
DOI10.1016/j.cub.2025.08.051
英文摘要Denisovan ancestry in present-day humans is heterogeneously distributed and comes from genetically distinct Denisovan groups. Understanding the origin of this heterogeneity could provide insights into the early population history of modern humans in Eurasia. However, population movements and admixture after the initial dispersals of modern humans have obscured the origin of this heterogeneity. To address this, we investigated how Denisovan ancestry in early modern humans relates to that in present-day humans. We found that varying levels of Denisovan ancestry in Eurasians were shaped by admixture between diverse early modern human lineages. In particular, ancient Japanese individuals from the Jomon period have the least Denisovan ancestry among individuals from Eastern Eurasia, providing evidence for an ancient East Asian lineage with little to no Denisovan ancestry. By contrast, the earliest mainland East Asians harbor the most Denisovan ancestry in Eastern Eurasia, including ancestry from multiple divergent Denisovan groups, already before the last glacial maximum. Together with evidence of Denisovan ancestry sharing among ancient and present-day genomes, these patterns show how Denisovan ancestry in Eurasia spread through gene flow from early East Asians. Our study provides the first systematic investigation of Denisovan admixture across time and extends our understanding of human population history in Eurasia.
WOS关键词COVERAGE NEANDERTHAL GENOME ; POPULATION HISTORY ; LATE PLEISTOCENE ; DNA ; CAVE ; NORTHERN ; SEQUENCE ; LANDSCAPE ; DIVERSITY ; ADMIXTURE
资助项目Max Planck Society ; European Research Council[1010424210]
WOS研究方向Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
语种英语
WOS记录号WOS:001604698100014
出版者CELL PRESS
源URL[http://119.78.100.205/handle/311034/25102]  
专题中国科学院古脊椎动物与古人类研究所
通讯作者Peter, Benjamin M.
作者单位1.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany
2.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing 100049, Peoples R China
3.Univ Rochester, Dept Biol, Rochester, NY 14620 USA
推荐引用方式
GB/T 7714		 Yang, Jiaqi,Iasi, Leonardo N. M.,Fu, Qiaomei,et al. An early East Asian lineage with unexpectedly low Denisovan ancestry[J]. CURRENT BIOLOGY,2025,35(20):4898-4908.
APA Yang, Jiaqi.,Iasi, Leonardo N. M..,Fu, Qiaomei.,Kelso, Janet.,Cooke, Niall P..,...&Peter, Benjamin M..(2025).An early East Asian lineage with unexpectedly low Denisovan ancestry.CURRENT BIOLOGY,35(20),4898-4908.
MLA Yang, Jiaqi,et al."An early East Asian lineage with unexpectedly low Denisovan ancestry".CURRENT BIOLOGY 35.20(2025):4898-4908.

入库方式： OAI收割

来源：古脊椎动物与古人类研究所

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