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The combined effects of visual impairment, hearing loss, and olfactory dysfunction on cognitive impairment: An individually matched case-control study

文献类型：期刊论文

作者Wu, Jing4,5; Yin, Xiangjun4; Liu, Yang4,6; Ji, Weiqiang6; Li, Jie7; Xiao, Gexin8; Zhang, Han4; Liu, Ce6; Wu, Xiaomin4; Xu, Jingyi1
刊名ALZHEIMERS & DEMENTIA
出版日期2025-08-01
卷号21期号:8页码:e70439
关键词case-control study cognitive impairment dementia elderly hearing loss mild cognitive impairment olfactory dysfunction sensory dysfunction subjective cognitive decline visual impairment
ISSN号1552-5260
DOI10.1002/alz.70439
产权排序6
文献子类Article
英文摘要INTRODUCTION The combined effects of visual impairment, hearing loss, and olfactory dysfunction on cognitive impairment remain unclear.METHODS We conducted a case-control study with 25,432 adults aged 60 years or older. We used multiple logistic regression to analyze the effects of combined visual impairment, hearing loss, and olfactory dysfunction on cognitive impairment, while controlling for confounding factors.RESULTS Single or combined visual impairment, hearing loss, and olfactory dysfunction negatively influenced cognitive impairment. Olfactory dysfunction had the greatest impact on dementia (odds ratio [OR] 2.37, 95% confidence interval 95% [CI] 2.01-2.79). For patients with combined sensory dysfunction, visual and olfactory dysfunction combined had the greatest impact on dementia (OR 6.50, 95% CI 3.78-11.20).DISCUSSION Visual impairment, hearing loss, and olfactory dysfunction, as noninvasive functional biomarkers, provide a viable approach for the early detection and prevention of cognitive impairment, and can be utilized as effective means of early diagnosis and pre-intervention of dementia.Highlights Olfactory dysfunction has a greater impact on cognition than visual impairment and hearing loss. The interaction of two sensory dysfunctions has a greater effect on cognition than one sensory dysfunction alone. Sensory dysfunction provides a viable approach for the early detection and prevention of cognitive impairment.
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WOS关键词DISEASE ; DEMENTIA ; OLDER
WOS研究方向Neurosciences & Neurology
语种英语
WOS记录号WOS:001560660600023
出版者WILEY
源URL[http://ir.igsnrr.ac.cn/handle/311030/216179]  
专题资源与环境信息系统国家重点实验室_外文论文
通讯作者Wu, Jing; Xu, Chengdong; Du, Qingfeng
作者单位1.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, A11 Datun Rd, Beijing 100101, Peoples R China;
2.Guangdong Prov Key Lab Chinese Med Pharmaceut, Guangzhou, Guangdong, Peoples R China
3.Southern Med Univ, Affiliated Hosp 7, Foshan, Guangdong, Peoples R China;
4.Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommunicable Dis Control & Pre, Beijing, Peoples R China;
5.Guangdong Basic Res Ctr Excellence Integrated Trad, Guangzhou, Guangdong, Peoples R China;
6.Southern Med Univ, Hosp Integrated Tradit Chinese & Western Med, Guangzhou, Guangdong, Peoples R China;
7.Guangzhou Univ, Sch Geog & Remote Sensing, Guangzhou, Guangdong, Peoples R China;
8.Natl Hlth Commiss, Natl Inst Hosp Adm, Beijing, Peoples R China;
9.Southern Med Univ, Sch Tradit Chinese Med, 1023-1063 Shatai South Rd, Guangzhou 510515, Guangdong, Peoples R China;
推荐引用方式
GB/T 7714		 Wu, Jing,Yin, Xiangjun,Liu, Yang,et al. The combined effects of visual impairment, hearing loss, and olfactory dysfunction on cognitive impairment: An individually matched case-control study[J]. ALZHEIMERS & DEMENTIA,2025,21(8):e70439.
APA Wu, Jing.,Yin, Xiangjun.,Liu, Yang.,Ji, Weiqiang.,Li, Jie.,...&Du, Qingfeng.(2025).The combined effects of visual impairment, hearing loss, and olfactory dysfunction on cognitive impairment: An individually matched case-control study.ALZHEIMERS & DEMENTIA,21(8),e70439.
MLA Wu, Jing,et al."The combined effects of visual impairment, hearing loss, and olfactory dysfunction on cognitive impairment: An individually matched case-control study".ALZHEIMERS & DEMENTIA 21.8(2025):e70439.

入库方式： OAI收割

来源：地理科学与资源研究所

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