Purpose Fast neutrons and gamma-ray imaging detection is an effective way to detect and identify radioactive material in the field of nuclear security. A compact coded aperture imaging (CAI) camera was designed to be sensitive to both gamma and neutron radiation based on plastic scintillators and multi-pixel photon counters (MPPC). Methods MPPCscoupling with the 13×13 pixelated plastic scintillators one-to-one were utilized to reduce the scale of the CAI system while maintaining good positional performance. The symmetric charge division (SCD) circuit was adopted to reduce the 169 signals output from the MPPC array to 26. Each waveform was collected and processed with four Domino Ring Sampler 4 (DRS4) chips and two 16-channel analog-to-digital converter (ADC) modules. As the pulse shapes of fast neutrons would be broadened after elastic scattering multiple times in the scintillators, the Anger-Logic method was applied to eliminate multiple elastic scattering events so that good pulse shape discrimination (PSD) performance can be achieved. Results Theimaginganddetectionabilityofthecamerawasevaluatedusingthe241Am-Be(5.9×105 n/s)neutronsourceand 137Cs(370MBq)gammasource.Thecameracanbeusedtodetectfastneutrons(0.5–10MeV)andgammarays(0.2–2.5MeV). Furthermore, it can implement efficient neutron/gamma PSD capabilities in the mixed-field environment. The figure of merit (FOM) of the camera calculated at 400keVee energy cut is 0.93. Conclusion A compact MPPC-based CAI camera was designed to detect and discriminate fast neutrons and gamma rays. Its good PSD performance was well suited to distinguish fast neutrons from gamma rays in a dual-particle environment. The portable design makes it promising for complex monitoring scenarios in nuclear security.