The tectono-magmatic event of the Changning-Menglian Paleo-Tethys orogen is an important process for understanding the tectonic evolution of the SE Tibetan Plateau. This orogen is composed of Changning-Menglian suture, Lancang group, Lincang batholith, and Yunxian volcanics. The Lincang batholith and its volcanic counterparts are part of Triassic magmatism in this orogen. The botholith is composed of biotite monzogranite, granodiorite and diorite. The Middle to Late Triassic volcanics include Manghuai rhyolite, Xiaodingxi basalt and Mengku dacite. The Mengku dacite is volcanic dome in west of the batholith. Lincang biotite monzogranite and Mengku dacite have similar geochemistry and are characterized by negative ε_Hf (t) values (–13.2 to –5.2) and ε_Nd (t) values (–14.7 to –8.8), whereas diorite dikes within the Lincang batholith have slightly high ε_Hf (t) values (–8.3 to –4.9) and ε_Nd (t) values (–6.9 to –6.7). Manifestations of resorption textures in quartz and reverse compositional zoning in feldspars are recognized from Mengku dacite. We consider that Mengku dacites resemble the erupted Lincang biotite monzogranite as they occur in the same tectonic settings and have similar geochemical features and mineral assemblages dominated by plagioclase, alkali-feldspar, quartz, and biotite. The evolution of the Mengku dacite magma is characterized by the rejuvenation of crystal mush represented by the Lincang batholith. The required thermal input was supplied by mafic magma, represented by diorite dikes and enclaves within the Lincang batholith. The Middle to Late Triassic magmatic event in this orogen likely resulted from lithospheric delamination and upwelling of the asthenosphere in a post-collisional environment.