Mid-Mesozoic gold deposits, whose metallogeny was coincident with subduction of the Paleo-Pacific plate, are widely distributed in the northern margin of the North China Craton (NCC). The genesis of these deposits is currently debated with magmatic- and metamorphic-hydrothermal models. In-situ analyses of sulfur isotopes and trace elements provide an opportunity to clarify such a debate. Here, the two techniques were used to determine the trace elements and sulfur isotopes of sulfides from three mid-Mesozoic gold deposits (Jiapigou, Jinchangyu, and Jinchanggouliang) in the northern margin of NCC. The Co/Ni ratios of pyrites suggest that Jiapigou and Jinchanggouliang deposits are of magmatic-hydrothermal origin, whereas the Jinchangyu deposits receive ore-forming materials mainly from crustal-hydrothermal fluids. In addition, gold-bearing sulfides display positive (5.60 ± 1.87 ‰, SD), near-zero (−0.31 ± 1.27 ‰, SD) and negative δ³⁴S_V-CDT values (−3.84 ± 2.97 ‰, SD) in the Jiapigou, Jinchangyu, and Jinchanggouliang, respectively. The results suggest that mid-Mesozoic gold deposits in the northern margin of NCC have variable sources of sulfur and metals. The Jiapigou deposit, representative of the arc settings, received sulfur and metals mainly from the subducting ocean crust. The Jinchanggouliang deposit, representative of cratonic destruction settings, received sulfur and metals mainly from the metasomastized mantle. The Jinchangyu deposit, representative of the back-arc settings, received sulfur and metals mainly from the metamorphic basement. We infer that subduction of the Paleo-Pacific plate in the mid-Mesozoic not only led to direct metallogeny of magmatic-hydrothermal gold deposits at arc settings and cratonic destruction settings, but also triggered the release of ore-forming fluids from the basement at back-arc, favoring metallogeny of crustal-hydrothermal gold deposits. Thus, mid-Mesozoic gold deposits in the northern margin of NCC cannot be exclusively explained by a single model.