In the region of large gas fields, extensive research has been conducted on earthquakes induced by industrial production in shale gas fields. However, limited attention has been given to the impact of post-earthquake events on shale gas reservoir leakage and fault activation. The Luxian M_S 6.0 earthquake, which occurred on 16 September 2021 in the Luzhou shale gas field, has raised concerns about post-earthquake shale gas leakage. Post-earthquake measurements of soil gases (Rn, CO₂, CH₄, and H₂) and isotopic analyses (δ¹³C_CO2, δ¹³C_CH4 and δD_CH4) in the Luzhou shale gas field area reveal that the Huayingshan fault zone, a natural pathway for shale gas leakage, was not activated by the Luxian earthquake and did not exhibit any further shale gas leakage after the 2021 earthquake. Furthermore, the seismogenic fault, which was impacted by the earthquake, did not damage the shale gas reservoir, causing shale gas leakage. This study provides an important foundation for future research on shale gas extraction and seismic activity in the region.