The extensively distributed Early Permian mafic rocks in the Qiangtang Terrane of the central Tibetan Plateau are the magmatic records of separation of this terrane from the Gondwana. Nevertheless, the origins and mantle source characteristics of these rocks continue to be subjects of debate. This study reports zircon U-Pb and Lu-Hf isotopic and whole-rock geochemical and Sr-Nd-Hf isotopic data on gabbros exposed in the Zougou Region, western Qiangtang Terrane. Our zircon U-Pb isotope age suggests that the Zougou gabbros (ZGs) were formed at ca. 290 Ma, representing newly discovered Early Permian mafic rocks within the Qiangtang Terrane. The ZGs display geochemical affinities with within-plate-basalts given that they are tholeiitic and have high Zr/Y and Ti/V ratios. Compared to previously examined Early Permian mafic rocks in the western Qiangtang Terrane, the ZGs are characterized by their distinct, nonradiogenic Nd (ε_Nd(t) = -0.54 to −2.18) isotopic signatures, which cannot be attributed to crustal contamination or assimilation. This assertion is supported by their uniform whole-rock ε_Nd(t), ε_Hf(t), and zircon ε_Hf(t) values, as well as by magma mixing modelling. In conjunction with regional geology, we propose that the ZGs were derived from an isotopically enriched lithospheric mantle metasomatized by previous subduction events. Furthermore, the positive decoupling of Hf-Nd isotopes (Δε_Hf(t) =  +2.21 to + 2.72), negative Nb-Ta anomalies, and variable Ba/Th ratios within the ZGs indicate that the metasomatic agents were fluids released from oceanic sediments. Our study provides insights into the compositions of the lithospheric mantle beneath the Qiangtang Terrane during the Permian, which is pivotal to discriminating the role of asthenospheric and lithospheric components in the formation of the contemporaneous mafic rocks in response to Gondwana break-up.