From a universal perspective, pressure is a key parameter in describing the thermodynamic state of matter. High-pressure materials science researchers delve deeply into this field to discover new crystallographic states and novel chemical properties in materials with multifunctional attributes. However, we are still in the early stages of understanding a great deal about how acoustic shock waves affect molecular crystals. In this study, we examine the impact of acoustic shock waves on L-phenylalanine (Form-III) polycrystalline samples. Conventional diffraction, microscopic, and vibrational spectroscopic techniques were employed to analyze the crystalline structure and surface morphological stability of these samples. Results from X-ray diffraction and scanning electron microscopy (SEM) indicate that the P2₁ space group and tablet-like morphology of L-phenylalanine remain unchanged even after exposure to 200 shocks. To provide a more comprehensive understanding of the structural and morphological stability, we compared our findings on L-phenylalanine with previously published results on L-tyrosine under the same shock exposure conditions. From a crystallographic and morphological standpoint, L-phenylalanine demonstrates higher shock resistance than L-tyrosine, suggesting its strong potential for pharmaceutical applications.