中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 海洋研究所
  3. 中国科学院海洋研究所
Regulation of Intestinal Inflammation in Large Yellow Croaker (Larimichthys crocea) by Soybean Globulin via Toll-Like Receptor Signaling

文献类型：期刊论文

作者Shao, Jianchun2,3; Jia, Nan3; Liu, Qianqian3; Zeng, Chao3; Zhang, Jiaonan1; Wang, Lei2; Zhao, Chao3; Chen, Xinhua3
刊名MOLECULAR NUTRITION & FOOD RESEARCH
出版日期2025-06-24
页码12
关键词intestinal inflammatory Larimichthys crocea pattern recognition receptor soybean globulin Toll-like receptor
ISSN号1613-4125
DOI10.1002/mnfr.70143
通讯作者Zhao, Chao(zhchao@live.cn) ; Chen, Xinhua(chenxinhua@tio.org.cn)
英文摘要Larimichthys crocea, an economically significant fish species, has experienced significant resource depletion due to overfishing, prompting the expansion of aquaculture. However, the utilization of plant-based protein sources, like soybean globulin, in aquafeeds may induce intestinal inflammation, compromising fish health. In this study, models of Toll-like receptor (TLR) gene expression were constructed using dual-luciferase reporter vectors. TLR5M and TLR5S were identified as key mediators of inflammatory responses through the activation of the MAPK and NF-kappa B signaling. Molecular docking analyses confirmed their high binding affinity with soybean globulin. Western blot analyses further validated significant changes in key proteins of these pathways. This study provides theoretical insights into plant protein-induced intestinal inflammation and supports the optimization of aquafeed formulations to enhance aquaculture efficiency.
WOS关键词DIGESTIVE ENZYMES ACTIVITY ; JAPANESE SEA-BASS ; NF-KAPPA-B ; FUNCTIONAL-CHARACTERIZATION ; FISH ; EXPRESSION ; GROWTH ; MEAL
资助项目National Key Research and Development Program of China ; National Natural Science Foundation of China[32373148] ; Fujian Science and Technology Department[2024J09027] ; Fujian Science and Technology Department[2024S0007] ; Seed Industry Innovation and Industrialization Project of Fujian Province[2021FJSCZY01] ; China Agricultural Research System[CARS47-G19] ; [2022YFD2401001]
WOS研究方向Food Science & Technology
语种英语
WOS记录号WOS:001513641900001
出版者WILEY
源URL[http://ir.qdio.ac.cn/handle/337002/202409]  
专题中国科学院海洋研究所
通讯作者Zhao, Chao; Chen, Xinhua
作者单位1.Fujian Tianma Sci & Technol Grp Co Ltd, Fujian Prov Key Lab Special Aquat Formula Feed, Fuzhou, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
3.Fujian Agr & Forestry Univ, Coll Marine Sci, State Key Lab Mariculture Breeding, Key Lab Marine Biotechnol Fujian Prov, Fuzhou, Peoples R China
推荐引用方式
GB/T 7714		 Shao, Jianchun,Jia, Nan,Liu, Qianqian,et al. Regulation of Intestinal Inflammation in Large Yellow Croaker (Larimichthys crocea) by Soybean Globulin via Toll-Like Receptor Signaling[J]. MOLECULAR NUTRITION & FOOD RESEARCH,2025:12.
APA Shao, Jianchun.,Jia, Nan.,Liu, Qianqian.,Zeng, Chao.,Zhang, Jiaonan.,...&Chen, Xinhua.(2025).Regulation of Intestinal Inflammation in Large Yellow Croaker (Larimichthys crocea) by Soybean Globulin via Toll-Like Receptor Signaling.MOLECULAR NUTRITION & FOOD RESEARCH,12.
MLA Shao, Jianchun,et al."Regulation of Intestinal Inflammation in Large Yellow Croaker (Larimichthys crocea) by Soybean Globulin via Toll-Like Receptor Signaling".MOLECULAR NUTRITION & FOOD RESEARCH (2025):12.

入库方式： OAI收割

来源：海洋研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。