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Identification of candidate genes associated with AHPND resistance based on genome-wide association study in Pacific white shrimp Litopenaeus vannamei

文献类型：期刊论文

作者Duan, Baohua2; Yu, Yang2,3; Bao, Zhenning1,2; Li, Fuhua2,3
刊名FISH & SHELLFISH IMMUNOLOGY
出版日期2025-12-01
卷号167页码:9
关键词Litopenaeus vannamei AHPND SNP Genome-wide association study
ISSN号1050-4648
DOI10.1016/j.fsi.2025.110663
通讯作者Yu, Yang(yuyang@qdio.ac.cn) ; Li, Fuhua(fhli@qdio.ac.cn)
英文摘要The Pacific white shrimp Litopenaeus vannamei (L. vannamei) is one of the most important mariculture species. A massive outbreak of acute hepatopancreatic necrosis disease (AHPND) resulted in a huge economic loss to the shrimp aquaculture industry. In this study, a total of 1033 individuals resistant and susceptible to AHPND were genotyped using a custom-designed SNP chip based on target sequencing technology. A total of 54,092 highquality single-nucleotide polymorphisms (SNPs) were obtained. A genome-wide association study (GWAS) identified 122 SNPs associated with the AHPND resistance traits in shrimp, including 2 genome-wide significant SNPs and 120 chromosome-wide SNPs. These SNPs were distributed across multiple chromosomes and formed a haplotype block on chr27, revealing the polygenic nature of AHPND resistance in L. vannamei. Additionally, 76 candidate genes were identified near these SNPs. Among them, translocon-associated protein subunit alpha (TRAP alpha) and sphingomyelin phosphodiesterase acid-like 3 (SMPDL3) were confirmed to be associated with this trait. These findings not only offer new insights into the genetic mechanisms underlying AHPND resistance in shrimp but also provide valuable genetic markers for molecular breeding in this species.
WOS关键词DISEASE ; PARAMETERS ; GROWTH ; VIRUS
资助项目National Key R & D Program of China[2022YFD2400203] ; National Natural Science Foundation of China[32473144] ; Key Research and Development Program of Shandong[2024LZGC038] ; Key Research and Development Program of Shandong[2021LZGC029] ; Postdoctoral Fellowship Program of CPSF[E4KY011] ; Taishan Scholars Program ; The earmarked fund for CARS-48 ; Taishan Scholars Program ; Oceano-graphic Data Center, IOCAS
WOS研究方向Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种英语
WOS记录号WOS:001563978900001
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
源URL[http://ir.qdio.ac.cn/handle/337002/203275]  
专题中国科学院海洋研究所
通讯作者Yu, Yang; Li, Fuhua
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, State Key Lab Breeding Biotechnol & Sustainable Aq, Qingdao 266000, Peoples R China
3.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Duan, Baohua,Yu, Yang,Bao, Zhenning,et al. Identification of candidate genes associated with AHPND resistance based on genome-wide association study in Pacific white shrimp Litopenaeus vannamei[J]. FISH & SHELLFISH IMMUNOLOGY,2025,167:9.
APA Duan, Baohua,Yu, Yang,Bao, Zhenning,&Li, Fuhua.(2025).Identification of candidate genes associated with AHPND resistance based on genome-wide association study in Pacific white shrimp Litopenaeus vannamei.FISH & SHELLFISH IMMUNOLOGY,167,9.
MLA Duan, Baohua,et al."Identification of candidate genes associated with AHPND resistance based on genome-wide association study in Pacific white shrimp Litopenaeus vannamei".FISH & SHELLFISH IMMUNOLOGY 167(2025):9.

入库方式： OAI收割

来源：海洋研究所

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