Comparative Transcriptomic and Proteomic Analyses Identify Byssogenesis-Associated Genes in the Mediterranean Mussel Mytilus galloprovincialis Lamarck, 1819
文献类型：期刊论文
| 作者 | Zhen, Xiuwei1,2,3; Chen, Yiwen2,3; Zhang, Wei2,3; Li, Yongren1; Li, Li4; Qi, Haigang4; Zhang, Shoudu2,3 |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2025-10-29 |
| 卷号 | 26期号:21页码:14 |
| 关键词 | |
| ISSN号 | 1661-6596 |
| DOI | 10.3390/ijms262110511 |
| 通讯作者 | Qi, Haigang(qihaigang@qdio.ac.cn) ; Zhang, Shoudu(shouduzhang@163.com) |
| 英文摘要 | Mussels' byssus and their adhesion ability play a crucial role in their attachment and artificial cultivation of mussels. In this study, transcriptomic and proteomic analyses were performed to identify byssogenesis-associated genes in the Mediterranean mussel Mytilus galloprovincialis Lamarck, 1819, seeking to advance our knowledge of the molecular basis of byssal secretion in mussels. Transcriptomic analysis identified 1742 and 1498 differentially expressed genes in the foot tissue of M. galloprovincialis at 9 h and 24 h post-byssal ablation, respectively. Meanwhile, proteomic analysis revealed 1254 and 484 differentially expressed proteins at the same two time points. Integrated analysis identified 121 genes differentially expressed at both transcript and protein levels. Among these genes, 44 were significantly upregulated, and they may constitute high-confidence gene sets associated with mussel byssogenesis. Notably, they included genes encoding tyrosinase-like protein, low affinity immunoglobulin epsilon Fc receptor, and O-methyltransferase MdmC. They were enriched in KEGG pathways, including metabolism of amino acids, lipid metabolism, nucleotide metabolism, and immune system. Quantitative real-time PCR was performed on seven selected genes, confirming that their expression patterns were consistent with those observed in transcriptomic and proteomic sequencing. This study provides novel data and insights for understanding the molecular basis involved in byssus development of M. galloprovincialis. |
| WOS关键词 | PROTEIN ; IDENTIFICATION ; ANTITHROMBIN |
| 资助项目 | Department of Science and Technology of Shandong Province[2024LZGCQY003] ; Department of Science and Technology of Shandong Province[2022LZGC015] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001612694700001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/203788]  |
| 专题 | 中国科学院海洋研究所 |
| 通讯作者 | Qi, Haigang; Zhang, Shoudu |
| 作者单位 | 1.Tianjin Agr Univ, Coll Fisheries, Tianjin 300384, Peoples R China 2.Natl Oceanog Ctr, Marine Sci Res Inst Shandong Prov, Qingdao 266104, Peoples R China 3.Shandong Key Lab Intelligent Marine Ranch Under Pr, Qingdao 266104, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhen, Xiuwei,Chen, Yiwen,Zhang, Wei,et al. Comparative Transcriptomic and Proteomic Analyses Identify Byssogenesis-Associated Genes in the Mediterranean Mussel Mytilus galloprovincialis Lamarck, 1819[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2025,26(21):14. |
| APA | Zhen, Xiuwei.,Chen, Yiwen.,Zhang, Wei.,Li, Yongren.,Li, Li.,...&Zhang, Shoudu.(2025).Comparative Transcriptomic and Proteomic Analyses Identify Byssogenesis-Associated Genes in the Mediterranean Mussel Mytilus galloprovincialis Lamarck, 1819.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,26(21),14. |
| MLA | Zhen, Xiuwei,et al."Comparative Transcriptomic and Proteomic Analyses Identify Byssogenesis-Associated Genes in the Mediterranean Mussel Mytilus galloprovincialis Lamarck, 1819".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 26.21(2025):14. |
入库方式： OAI收割
来源：海洋研究所
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