Highly oxygenated acorane sesquiterpenes from the marine-sourced Trichoderma harzianum CS-152
文献类型：期刊论文
| 作者 | Li, Yan-He1,2,3; Li, Xiao-Ming1,3; Li, Xin1,3; Shi, Xiao-Shan1,3; Yang, Sui-Qun1,3; Li, Hong-Lei1,3; Wang, Bin-Gui1,2,3 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2025-09-01 |
| 卷号 | 185页码:5 |
| 关键词 | Cold-seep Deep sea-derived fungus Trichoderma harzianum Acorane sesquiterpenes Antibacterial activity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2025.106672 |
| 通讯作者 | Li, Hong-Lei(lihonglei@qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| 英文摘要 | Three new highly oxygenated acorane sesquiterpenes, namely, 9,10-epoxidicacoren-2,7,8-triol (1), 8S-acoren-2,7,8-triol (2), and 8R-acoren-2,7,8-triol (3), along with four known analogs (4-7), were isolated from the deepsea derived fungus Trichoderma harzianum CS-152. Except for compound 7, the other compounds lack conjugation and do not exhibit fluorescence under UV light at 254 nm, which posed a challenge in their detection and required careful monitoring during separation. The isolation and purification of these compounds was achieved using traditional silica gel column chromatography. Their chemical structures and relative configurations were elucidated by comprehensive analysis of 1D/2D NMR, HRESIMS, and their absolute configurations were determined by modified Mosher's method. Compounds 1 and 4 displayed inhibitory activities against the aquatic pathogen Aeromonas hydrophila, each with a MIC value 4 mu g/mL, while compound 7 showed antibacterial activity against Pseudomonas aeruginosa with a MIC value 4 mu g/mL. |
| 资助项目 | Shandong Provincial Natural Science Foundation[ZR2021ZD28] ; National Natural Science Foundation of China[U2006203] ; National Natural Science Foundation of China[42276109] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001516709400003 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/201997]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Li, Hong-Lei; Wang, Bin-Gui |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 3.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yan-He,Li, Xiao-Ming,Li, Xin,et al. Highly oxygenated acorane sesquiterpenes from the marine-sourced Trichoderma harzianum CS-152[J]. FITOTERAPIA,2025,185:5. |
| APA | Li, Yan-He.,Li, Xiao-Ming.,Li, Xin.,Shi, Xiao-Shan.,Yang, Sui-Qun.,...&Wang, Bin-Gui.(2025).Highly oxygenated acorane sesquiterpenes from the marine-sourced Trichoderma harzianum CS-152.FITOTERAPIA,185,5. |
| MLA | Li, Yan-He,et al."Highly oxygenated acorane sesquiterpenes from the marine-sourced Trichoderma harzianum CS-152".FITOTERAPIA 185(2025):5. |
入库方式： OAI收割
来源：海洋研究所
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