Ctnnb1 and Keap1-Nrf2 mediating divergent heat resistance in two congeneric oysters
文献类型：期刊论文
| 作者 | Chen, Jincheng1,4,5,6; Wang, Chaogang2,3,4,6; Du, Mingyang1,4; Jiang, Zhuxiang1,4; Cong, Rihao2,4,5; Wang, Wei2,3,4; Qi, Haigang2,4,5; Liu, Mingkun2,4; Zhang, Guofan2,5,6; Li, Li1,2,3,4,6 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2025-06-01 |
| 卷号 | 311页码:12 |
| 关键词 | Antioxidant capacity Nuclear factor erythroid 2-related factor 2 Transcriptional and post-translational regulation |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2025.143183 |
| 通讯作者 | Li, Li(lili@qdio.ac.cn) |
| 英文摘要 | Global warming has led to rising temperatures of sea, which in turn increases oxidative stress on marine organisms. The Nuclear factor erythroid 2-related factor 2 (Nrf2), as widely recognized antioxidative transcription factor, has been reported playing a significant role in the thermal stress response of marine organisms; however, its precise function and regulatory mechanisms remain unclear. In this study, we demonstrated regulatory mechanisms of Nrf2 in two congeneric oyster species with differential thermal tolerance Crassostrea gigas (C. gigas) and Crassostrea angulata (C. angulata). Firstly, we confirmed that Nrf2 can activate the expression of antioxidant (including Ggt1, Segpx) and immune-related genes (including Cebpg), while inhibiting the expression of pro-oxidant genes (including Cyp-13B1). Moreover, the upstream regulatory factors (Ctnnb1 and Keap1), acting as temperature sensors, modulate the expression abundance of Nrf2 in oysters at transcriptional and posttranslational levels to mitigate heat-induced oxidative stress. And their differential expression patterns are involved in shaping higher antioxidant capacity and thermal tolerance in C. angulata. This study firstly characterized the Nrf2 gene function and its regulatory network (Ctnnb1 and Keap1-Nrf2) in marine organisms, providing new insights for assessing the adaptive potential heat tolerance of oysters and other marine species facing the threat of global warming. |
| WOS关键词 | GAMMA-GLUTAMYL-TRANSPEPTIDASE ; OXIDATIVE STRESS ; ANTIOXIDANT RESPONSE ; HELICOBACTER-PYLORI ; CRASSOSTREA-GIGAS ; IMMUNE-RESPONSE ; PACIFIC OYSTERS ; OXYGEN RADICALS ; BETA-CATENIN ; NRF2 |
| 资助项目 | National Key Research and Development Program of China[2022YFD2400304] ; Key Research and Development Program of Shandong Province[2022LZGC015] ; Key Research and Development Program of Shandong Province[ZFJH202309] ; Key Research and Development Program of Shandong Province[2024LZGCQY003] ; Agriculture Research System of China of MOF and MARA[CARS-49] ; Department of Science and Technology of Shandong Province[2022GJJLJRC02-096] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001492225400014 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/202085]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Li, Li |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China 3.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China 4.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao, Peoples R China 5.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 6.Chinese Acad Sci, State Key Lab Breeding Biotechnol & Sustainable Aq, Inst Oceanol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jincheng,Wang, Chaogang,Du, Mingyang,et al. Ctnnb1 and Keap1-Nrf2 mediating divergent heat resistance in two congeneric oysters[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2025,311:12. |
| APA | Chen, Jincheng.,Wang, Chaogang.,Du, Mingyang.,Jiang, Zhuxiang.,Cong, Rihao.,...&Li, Li.(2025).Ctnnb1 and Keap1-Nrf2 mediating divergent heat resistance in two congeneric oysters.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,311,12. |
| MLA | Chen, Jincheng,et al."Ctnnb1 and Keap1-Nrf2 mediating divergent heat resistance in two congeneric oysters".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 311(2025):12. |
入库方式： OAI收割
来源：海洋研究所
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