Three New Meroterpenoids With Antimicrobial Activity Characterized From the Cold-seep-derived Alternaria alstroemeriae CS-745
文献类型：期刊论文
| 作者 | Dong, Guan-Hai1,2,3; Li, Xiao-Ming1,3; Wang, Bin-Gui1,2,3; Meng, Ling-Hong1,2,3 |
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2025-06-06 |
| 页码 | 8 |
| 关键词 | |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202501369 |
| 通讯作者 | Wang, Bin-Gui(wangbg@qdio.ac.cn) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn) |
| 英文摘要 | Three new meroterpenoids, tricycloalternarenes P and Z (1 and 2), and didehydrotricycloalternarene Z (3), together with nine known congeners (4-12), were obtained from the culture of Alternaria alstroemeriae, a fungus isolated from the sunken logs collected from the cold seep environment in the South China Sea. Their structures were determined by detailed interpretation of nuclear magnetic resonance (NMR) spectroscopy spectroscopic and mass spectrometric data. The relative configurations of compounds 1-3 were assigned by nuclear Overhauser effect spectroscopy correlations combined with gauge-independent atomic orbital NMR shift calculations and DP4+ probability analysis, while their absolute configurations were assigned by time-dependent density functional theory electronic circular dichroism calculations. The biological analysis results revealed that compounds 1-4, 7, and 9-11 showed antibacterial activities against Klebsiella pneumonia and methicillin-resistant Staphylococcus aureus with minimum inhibitory concentrations of 22.2-100 mu M. |
| WOS关键词 | MIXED TERPENOIDS |
| 资助项目 | National Natural Science Foundation of China[U2006203] ; National Natural Science Foundation of China[42176115] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001503190200001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/202157]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Bin-Gui; Meng, Ling-Hong |
| 作者单位 | 1.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Guan-Hai,Li, Xiao-Ming,Wang, Bin-Gui,et al. Three New Meroterpenoids With Antimicrobial Activity Characterized From the Cold-seep-derived Alternaria alstroemeriae CS-745[J]. CHEMISTRY & BIODIVERSITY,2025:8. |
| APA | Dong, Guan-Hai,Li, Xiao-Ming,Wang, Bin-Gui,&Meng, Ling-Hong.(2025).Three New Meroterpenoids With Antimicrobial Activity Characterized From the Cold-seep-derived Alternaria alstroemeriae CS-745.CHEMISTRY & BIODIVERSITY,8. |
| MLA | Dong, Guan-Hai,et al."Three New Meroterpenoids With Antimicrobial Activity Characterized From the Cold-seep-derived Alternaria alstroemeriae CS-745".CHEMISTRY & BIODIVERSITY (2025):8. |
入库方式： OAI收割
来源：海洋研究所
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