Comprehensive analysis of salicylic acid-derivatized alginate: Synthesis, characterization, and anti-acne potential
文献类型：期刊论文
| 作者 | Yuan, Mengyao1,2,3; Liu, Lijia1,2,3; Ma, Xiaoqing1,2,3; Geng, Lihua1,2,4; Wang, Xiuliang1,2,4; Wu, Ning1,2,4; Yue, Yang1,2,4; Zhang, Quanbin1,2,4; Wang, Jing1,2,4 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2025-09-15 |
| 卷号 | 364页码:14 |
| 关键词 | Alginate-derivative Salicylic acid grafted alginate Anti-acne Anti-bacterial Lipid regulate Bioactive composite |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2025.123776 |
| 通讯作者 | Wang, Jing(jingwang@qdio.ac.cn) |
| 英文摘要 | Salicylic acid (SA) is commonly utilized in the early treatment of acne due to its therapeutic efficacy. However, its clinical performance is hindered by limited aqueous solubility, stability and potential for irritation. This study addresses these challenges through deriving SA with alginate (SA-g-Alg) based on a complementary advantages strategy, designed to retain the bioactivity of SA while mitigating its drawbacks. A comprehensive investigation into the structure, physiochemical properties and anti-acne bioactivities of SA-g-Alg was conducted. The results demonstrate that SA-g-Alg achieved a 30-fold higher aqueous stability compared to free SA, along with enhanced moisturizing capacity and reduced cytotoxicity and skin irritation. These enhancements were attributed to the multi-hydroxy and inherent high biocompatibility of alginate. It is noteworthy that SA-g-Alg, with a grafting degree of 24.9 %, exhibited a synergistic effect, as evidenced by its superior lipid regulating ability, comparable antibacterial efficacy and prolonged anti-inflammatory bioavtivity compared to equivalent salicylic acid group in free SA. Moreover, in vivo studies employing a rabbit ear acne model show that a 2 % SA-g-Alg formulation was as effective as a clinical established 2 % SA ointment in therapeutic management of acne. In conclusion, this study underscores the enhanced physiochemical and anti-acne properties of SA-g-Alg, highlighting its potential as a promising therapeutic agent for the treatment of mild to moderate acne. |
| WOS关键词 | COMBINATION ; EFFICACY ; PEEL ; SKIN |
| 资助项目 | National key R & D Program of China[2023YFE0106200] ; Shandong Provincial Natural Science Founda-tion[ZR2022MD007] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001498582200001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/202175]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wang, Jing |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, 168 Wenhai Rd, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Mengyao,Liu, Lijia,Ma, Xiaoqing,et al. Comprehensive analysis of salicylic acid-derivatized alginate: Synthesis, characterization, and anti-acne potential[J]. CARBOHYDRATE POLYMERS,2025,364:14. |
| APA | Yuan, Mengyao.,Liu, Lijia.,Ma, Xiaoqing.,Geng, Lihua.,Wang, Xiuliang.,...&Wang, Jing.(2025).Comprehensive analysis of salicylic acid-derivatized alginate: Synthesis, characterization, and anti-acne potential.CARBOHYDRATE POLYMERS,364,14. |
| MLA | Yuan, Mengyao,et al."Comprehensive analysis of salicylic acid-derivatized alginate: Synthesis, characterization, and anti-acne potential".CARBOHYDRATE POLYMERS 364(2025):14. |
入库方式： OAI收割
来源：海洋研究所
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