Exploring hypoxia-triggered edema in sea cucumbers: Molecular perspectives on environmental stress
文献类型：期刊论文
| 作者 | Huo, Da3,4,5; Russell, Bayden1,2,7; Su, Fang3,4,5; Liu, Botao3,4,5; Zhang, Libin3,4,5; Yang, Hongsheng3,4,5; Sewell, Mary A.6; Sun, Lina3,4,5 |
| 刊名 | AQUACULTURE
 |
| 出版日期 | 2025-10-15 |
| 卷号 | 609页码:10 |
| 关键词 | Apostichopus japonicus RNA sequencing Anoxia Swollen Hydropsy Edema |
| ISSN号 | 0044-8486 |
| DOI | 10.1016/j.aquaculture.2025.742857 |
| 通讯作者 | Sun, Lina(sunlina@qdio.ac.cn) |
| 英文摘要 | Intensified human activities in coastal zones (e.g. nutrient pollution, coastal development) and climate change reduce solubility and enhance water stratification, and have been driving the expansion and intensification of hypoxic zones globally. When exposed to hypoxic stress, some sea cucumbers become edematous (swollen with excessive fluid) and are more susceptible to mortality. However, the difference of specific phenotype indicators between edematous sea cucumber and non-edematous sea cucumber, and the mechanism underpinning edematous is not clear. Here, we exposed the ecologically valuable sea cucumbers species Apostichopus japonicus, which has an economic impact of >US$45 bn annually, to acute hypoxia (2 mg/L) to elucidate the physiological and molecular mechanisms which underpin edematous. We found that the percent of body wall weight (Wbw) in wet weight (Ww) was higher in normoxia sea cucumbers (53.49 %-53.80 %) than edematous sea cucumbers (43.32 %-44.80 %), indicating edematous sea cucumber contains excessive seawater inside the body to transport more oxygen to cope with hypoxia. The co-identified up-regulated mRNAs (i.e. ficolin-2, metalloproteinase inhibitor 3-like, and complement component C3) and down-regulated mRNAs (i.e. receptor-type tyrosine-protein phosphatase epsilon, PR domain zinc finger protein 2, and protein NLRC5-like) in both respiratory tree and tube foot were crucial. In edematous sea cucumbers, up-regulated genes were largely involved in "metabolism of cofactors and vitamins" and "folding, sorting and degradation," while genes involved in "signal transduction" and "immune system" were largely down-regulated. Retinol metabolism and Phospholipase D signaling pathways participated in regulating sea cucumber edema but have varied patterns. Overall, we provide insights into the molecular mechanism underpinning sea cucumber edema and help to understand the response of sea cucumbers to increasingly oxygen-limited future oceans. |
| WOS关键词 | EXPRESSION ANALYSIS ; TRANSCRIPTOME ; ORGANIZATION ; SEGREGATION ; RESPONSES ; PROTEINS ; DISEASE ; CARPIO ; GENES ; RBX1 |
| 资助项目 | National Key Research and Development Program of China[2022YFF0802202] ; National Natural Science Foundation of China[42106106] ; National Natural Science Foundation of China[42261160378] ; Shandong Provincial Natural Science Foundation[ZR2021QD013] ; Special Funds for the Central Government to Guide Local Science and Technology Development[YDZX2023043] ; Postdoctoral Innovative Talents Support Program of Shandong Province[SDBX2020006] ; Special Research Assistant Project of Chinese Academy of Sciences ; Taishan Scholars Program (Youth Taishan Scholars)[tsqn202306287] |
| WOS研究方向 | Fisheries ; Marine & Freshwater Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001519165500001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/202424]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Sun, Lina |
| 作者单位 | 1.Univ Hong Kong, Inst Climate & Carbon Neutral, Hong Kong, Peoples R China 2.Univ Hong Kong, Swire Inst Marine Sci & Area Ecol & Biodivers, Sch Biol Sci, Hong Kong, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Breeding Biotechnol & Sustainable Aquacult, 7 Nanhai Rd, Qingdao 266071, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 6.Univ Auckland, Sch Biol Sci, Auckland, New Zealand 7.Univ Hong Kong, Swire Inst Marine Sci, Joint Lab Marine Ecol & Environm Sci JLMEES, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huo, Da,Russell, Bayden,Su, Fang,et al. Exploring hypoxia-triggered edema in sea cucumbers: Molecular perspectives on environmental stress[J]. AQUACULTURE,2025,609:10. |
| APA | Huo, Da.,Russell, Bayden.,Su, Fang.,Liu, Botao.,Zhang, Libin.,...&Sun, Lina.(2025).Exploring hypoxia-triggered edema in sea cucumbers: Molecular perspectives on environmental stress.AQUACULTURE,609,10. |
| MLA | Huo, Da,et al."Exploring hypoxia-triggered edema in sea cucumbers: Molecular perspectives on environmental stress".AQUACULTURE 609(2025):10. |
入库方式： OAI收割
来源：海洋研究所
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