MAPK/ERK-driven transcriptional regulation mediates divergent thermal tolerance in two congeneric oyster species
文献类型：期刊论文
| 作者 | Wang, Min4,5,6,7; Wang, Chaogang1,3,5; Du, Mingyang4,5; Jiang, Zhuxiang4,5; Chen, Jincheng4,5; Cong, Rihao1,2,5,6; Wang, Wei1,2,5; Zhang, Guofan1,2,3,5,6,7; Li, Li1,2,3,4,5,7 |
| 刊名 | AQUACULTURE
 |
| 出版日期 | 2025-10-15 |
| 卷号 | 609页码:13 |
| 关键词 | Crassostrea gigas Crassostrea angulata MAPK/ERK pathway Transcriptional regulation Thermal tolerance |
| ISSN号 | 0044-8486 |
| DOI | 10.1016/j.aquaculture.2025.742855 |
| 通讯作者 | Li, Li(lili@qdio.ac.cn) |
| 英文摘要 | Oysters, globally distributed filter-feeding bivalves, are ecologically and economically vital, yet summer mass mortality events due to global warming threaten their sustainable development. ERK1/2 function as a phosphorylation-activated molecular switch in MAPK pathway, transducing thermal stress signals via nuclear translocation and transcription factor interaction to regulate thermotolerance-related genes expression in oysters. In this study, we comprehensively investigated the transcriptional regulatory role of ERK kinase in oyster thermotolerance through combined treatment with ERK kinase inhibitors and heat stress, integrated with RNA-Seq and physiological/biochemical assays. Our data demonstrate that ERK, under heat stress, activated phagocytosis (Drpr, Sqstm1), coordinated intricate pathway cross-talk among PI3K-AKT pathway, mTOR pathway, and NF-& kgreen;B signaling pathway (Fos, Trpm2, Pik3ca), inhibited apoptosis (Birc3, Bax, Bcl-2), and optimizing energy conversion processes (HK, PK, C1qtnf3, Fasn). The integrated transcriptomic analysis of Crassostrea gigas and Crassostrea angulata further confirmed the critical role of ERK-regulated genes in thermal adaptation. This study elucidates the transcriptional regulation network of MAPK/ERK pathway in oyster thermotolerance, and advancing our mechanistic understanding of heat resilience in marine invertebrates. Meanwhile, the identified molecular regulators provide actionable targets for breeding heat-resistant oyster strains, offering a dual foundation for both ecological conservation and sustainable oyster aquaculture in the context of global warming. |
| WOS关键词 | PROTEIN-KINASE CASCADES ; STRESS ; PHAGOCYTOSIS ; EXPRESSION ; AUTOPHAGY ; ACCUMULATION ; RECOGNITION ; ACTIVATION ; MECHANISMS ; TFIIH |
| 资助项目 | Key Research and Development Program of Shandong[2024LZGCQY003] ; Department of Science and Technology of Shandong Province[2022GJJLJRC02-096] ; Agriculture Research System of China of MOF[CARS-49] |
| WOS研究方向 | Fisheries ; Marine & Freshwater Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001518826600001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/202436]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Li, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China 2.Shandong Technol Innovat Ctr Oyster Seed Ind, Qingdao, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, State Key Lab Breeding Biotechnol & Sustainable Aq, Wuhan, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao, Peoples R China 6.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 7.Chinese Acad Sci, Inst Oceanol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Min,Wang, Chaogang,Du, Mingyang,et al. MAPK/ERK-driven transcriptional regulation mediates divergent thermal tolerance in two congeneric oyster species[J]. AQUACULTURE,2025,609:13. |
| APA | Wang, Min.,Wang, Chaogang.,Du, Mingyang.,Jiang, Zhuxiang.,Chen, Jincheng.,...&Li, Li.(2025).MAPK/ERK-driven transcriptional regulation mediates divergent thermal tolerance in two congeneric oyster species.AQUACULTURE,609,13. |
| MLA | Wang, Min,et al."MAPK/ERK-driven transcriptional regulation mediates divergent thermal tolerance in two congeneric oyster species".AQUACULTURE 609(2025):13. |
入库方式： OAI收割
来源：海洋研究所
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