The anti-hyperuricemia effects of polysaccharide from Saccharina japonica through gut-kidney axis
文献类型：期刊论文
| 作者 | Yu, Haoyu2,3,4,5; Dong, Kai2,3; Fu, Mengying2,3,4,5; Wang, Hui2,3,4,5; Wang, Jing1,2,3; Zhang, Quanbin1,2,3; Yue, Yang1,2,3; Geng, Lihua1,2,3; Wu, Ning1,2,3,4,5 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2025-08-01 |
| 卷号 | 319页码:12 |
| 关键词 | Saccharina japonica Heteropolysaccharide Anti-hyperuricemia Gut-kidney axis |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2025.145336 |
| 通讯作者 | Wu, Ning(wuning@qdio.ac.cn) |
| 英文摘要 | Hyperuricemia (HUA), a global health burden affecting adults, drives progressive renal dysfunction and chronic inflammation. Current therapies exhibit limited efficacy and renal toxicity, necessitating safer multi-target agents. Here, we characterize a marine-derived heteropolysaccharide (SHP) from Saccharina japonica and demonstrate its pleiotropic anti-hyperuricemia effects. Hyperuricemic mice were established to evaluate antihyperuricemic effect of SHP. The correlative general physical parameters, renal histopathology, renal gene expressions, and gut microbiome were investigated in hyperuricemic mice by an enzyme-linked immunosorbent assay (ELISA), western blotting and immunohistochemistry (IHC). Our results demonstrated that treatment with SHP significantly reduced serum uric acid, serum urea, and creatinine levels compared to the BLK group. Additionally, SHP downregulated inflammatory markers, and alleviated renal injury. Western blotting and IHC analyses revealed that SHP treatment upregulated the expression of key urate transporters, ABCG2 and galectin9. Furthermore, 16S rRNA gene sequencing indicated that SHP modulated the gut microbiota by increasing the abundance of Lactobacillus. Together, this study provides experimental evidence that the potential of SHP as a natural therapeutic agent for hyperuricemia-related disorders. And also, this work providing new insights into multi-target therapeutic strategies and the critical link between natural polysaccharides and metabolic regulation. |
| WOS关键词 | URIC-ACID ; METABOLISM ; FUCOIDAN ; CHALLENGES ; UPDATE |
| 资助项目 | National Natural Science Foundation of China[42176137] ; Natural Science Foundation of Nantong[JC2023088] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001525360300012 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/202544]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wu, Ning |
| 作者单位 | 1.Nantong Zhongke Marine Sci & Technol Res & Dev Ctr, Nantong, Peoples R China 2.Chinese Acad Sci, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 4.Qingdao Marine Sci & Technol Ctr, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Haoyu,Dong, Kai,Fu, Mengying,et al. The anti-hyperuricemia effects of polysaccharide from Saccharina japonica through gut-kidney axis[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2025,319:12. |
| APA | Yu, Haoyu.,Dong, Kai.,Fu, Mengying.,Wang, Hui.,Wang, Jing.,...&Wu, Ning.(2025).The anti-hyperuricemia effects of polysaccharide from Saccharina japonica through gut-kidney axis.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,319,12. |
| MLA | Yu, Haoyu,et al."The anti-hyperuricemia effects of polysaccharide from Saccharina japonica through gut-kidney axis".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 319(2025):12. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。