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Unravelling the regulatory network underlying divergent expression of the key lipid metabolism transcription factor SREBP in two congeneric oyster species

文献类型：期刊论文

作者Du, Mingyang2,3,4,5; Bu, Tian3,4; Wang, Chaogang4,6,7; Chen, Jincheng4,5; Jiang, Zhuxiang4,5; Wang, Min4,5; Pang, Meiqian3,4; Cong, Rihao1,3,4,7; Wang, Wei4,6,7; Zhang, Guofan1,2,3,4,7,8
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
出版日期2025-08-01
卷号320页码:13
关键词Lipid metabolism SREBP Oysters
ISSN号0141-8130
DOI10.1016/j.ijbiomac.2025.145808
通讯作者Li, Li(lili@qdio.ac.cn)
英文摘要SREBP serves as the master transcriptional regulator of lipid metabolism, playing a crucial role in temperature adaptation. However, the regulatory mechanisms controlling SREBP expression remain poorly understood in marine organisms. The basic bHLH domain of single-copy SREBP was highly conserved in mollusks, confirming its fundamental role in lipid metabolic regulation. We observed significantly higher SREBP gene expression in the relatively cold-adapted Crassostrea gigas compared to the warm-adapted Crassostrea angulata. The large and stably inherited deletion in the SREBP promoter region of C. gigas prevented binding of repressive transcription factor POU4F3, partially explaining its higher expression levels. Additionally, the eGWAS analysis identified 119 candidate genes potentially associated with SREBP expression regulation. The direct interaction of SREBP with PPP6C and the non-binding PRP4 may activate downstream regulatory pathways of SREBP through phosphorylation mechanisms. The higher expressed activating transcription factor PRRX2 in C. gigas could simultaneously activate the promoter activity in both oyster species, potentially explaining the elevated expression of SREBP in C. gigas. This study provided the first comprehensive characterization the regulatory network of SREBP expression in marine organisms, providing new insights into lipid metabolism for temperature adaptation in the context of global warming.
WOS关键词ELEMENT-BINDING PROTEIN ; GENE-REGULATION ; CIS ; PHOSPHORYLATION ; PROMOTER
资助项目National Key R&D Program of China[2022YFD2400304] ; Key Research and Development Program of Shandong[2024LZGCQY003] ; Key Research and Development Program of Shandong[2022LZGC015] ; Key Research and Development Program of Shandong[ZFJH202309] ; Taishan Scholars Program[tsqn202312267] ; Department of Science & Technology of Shandong Province[2022GJJLJRC02-096] ; China Agriculture Research System of MOF and MARA[CARS-49] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[2023215]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种英语
WOS记录号WOS:001532037900001
出版者ELSEVIER
源URL[http://ir.qdio.ac.cn/handle/337002/202613]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Li, Li
作者单位1.Shandong Ctr Technol Innovat Oyster Seed Ind, Qingdao, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Wuhan, Peoples R China
3.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
4.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao, Peoples R China
5.Univ Chinese Acad Sci, Beijing, Peoples R China
6.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China
7.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China
8.Southern Marine Sci & Engn Guangdong Lab Zhanjiang, Zhanjiang, Peoples R China
推荐引用方式
GB/T 7714		 Du, Mingyang,Bu, Tian,Wang, Chaogang,et al. Unravelling the regulatory network underlying divergent expression of the key lipid metabolism transcription factor SREBP in two congeneric oyster species[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2025,320:13.
APA Du, Mingyang.,Bu, Tian.,Wang, Chaogang.,Chen, Jincheng.,Jiang, Zhuxiang.,...&Li, Li.(2025).Unravelling the regulatory network underlying divergent expression of the key lipid metabolism transcription factor SREBP in two congeneric oyster species.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,320,13.
MLA Du, Mingyang,et al."Unravelling the regulatory network underlying divergent expression of the key lipid metabolism transcription factor SREBP in two congeneric oyster species".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 320(2025):13.

入库方式： OAI收割

来源：海洋研究所

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