A Novel Exopolysaccharide, Highly Prevalent in Marine Spongiibacter, Triggers Pyroptosis to Exhibit Potent Anticancer Effects
文献类型：期刊论文
| 作者 | Liu, Ge1,2,3,4,5; Shan, Yeqi1,2,3,4,5; Sun, Chaomin1,2,3,4,5 |
| 刊名 | FASEB JOURNAL
 |
| 出版日期 | 2025-07-23 |
| 卷号 | 39期号:14页码:11 |
| 关键词 | anti-tumor cell death marine bacterial exopolysaccharide pyroptosis |
| ISSN号 | 0892-6638 |
| DOI | 10.1096/fj.202500412R |
| 通讯作者 | Sun, Chaomin(sunchaomin@qdio.ac.cn) |
| 英文摘要 | Pyroptosis is an inflammatory programmed cell death. In recent years, the potential of pyroptosis in tumor treatment has received widespread attention and has become a promising anti-tumor therapeutic strategy. EPS3.9 is a novel deep-sea bacterial exopolysaccharide that we obtained and has potent anti-tumor activity. EPS3.9 consisted of mannose and glucose with a molar ratio of 1:0.42. The average molecular weight of EPS3.9 was 17.1 kDa. EPS3.9 can induce lytic cell death in tumor cells. Mechanism analysis has revealed that it can directly target 5 membrane phospholipids and exert tumor cytotoxic activity through triggering NLRP3 inflammasome-mediated pyroptosis in the human monocytic leukemia THP-1 cells. EPS3.9 also has significant anti-tumor effects in Huh7.5 tumor-bearing mice and can activate anti-tumor immune responses. Besides, this active exopolysaccharide is ubiquitous among the genus Spongiibacter. This study provides an important theoretical basis for EPS3.9 as a new type of marine carbohydrate anti-tumor drug candidate and also provides scientific evidence for the feasibility and potential of tumor treatment by triggering pyroptosis. |
| WOS关键词 | INFLAMMASOME ACTIVATION ; GASDERMIN D ; DRUGS |
| 资助项目 | Science and Technology Innovation Project[2022QNLM030004-3] ; Science and Technology Innovation Project[LSKJ202203103] ; Science and Technology Innovation Project of Laoshan Laboratory[ZR2024ZD49] ; Shandong Provincial Natural Science Foundation[42221005] ; NSFC Innovative Group Grant[E42424101N] ; Qingdao West Coast New District University Presidents Fund[tstp20230637] ; Taishan Scholars Program |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001534257400001 |
| 出版者 | WILEY |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/202671]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Sun, Chaomin |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Deep Sea Res, Qingdao, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Chinese Acad Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 5.Chinese Acad Sci, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ge,Shan, Yeqi,Sun, Chaomin. A Novel Exopolysaccharide, Highly Prevalent in Marine Spongiibacter, Triggers Pyroptosis to Exhibit Potent Anticancer Effects[J]. FASEB JOURNAL,2025,39(14):11. |
| APA | Liu, Ge,Shan, Yeqi,&Sun, Chaomin.(2025).A Novel Exopolysaccharide, Highly Prevalent in Marine Spongiibacter, Triggers Pyroptosis to Exhibit Potent Anticancer Effects.FASEB JOURNAL,39(14),11. |
| MLA | Liu, Ge,et al."A Novel Exopolysaccharide, Highly Prevalent in Marine Spongiibacter, Triggers Pyroptosis to Exhibit Potent Anticancer Effects".FASEB JOURNAL 39.14(2025):11. |
入库方式： OAI收割
来源：海洋研究所
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