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A glycogen derived from sea urchin-Strongylocentyotus internedius shifts macrophages to the M1 phenotype and enhances the anti-pancreatic cancer activity of gemcitabine

文献类型：期刊论文

作者Deng, Zhenzhen2,3,4; Yu, Haoyu2,3,4; Wu, Ning1,4; Wang, Qingchi5; Wang, Jing3,4; Yue, Yang3,4; Geng, Lihua3,4; Zhang, Quanbin2,3,4
刊名FRONTIERS IN PHARMACOLOGY
出版日期2025-07-25
卷号16页码:12
关键词glycogen tumor microenvironment JAK STAT signaling pathway gemcitabine macrophages
DOI10.3389/fphar.2025.1600349
通讯作者Wu, Ning(wuning@qdio.ac.cn) ; Zhang, Quanbin(qbzhang@qdio.ac.cn)
英文摘要One of the biggest obstacles to treating pancreatic ductal adenocarcinoma (PDAC) is chemotherapy resistance. Macrophages are an essential element of the innate immune system and are distributed in almost every tissue in the body. Among them, macrophages infiltrating into the tumor microenvironment negatively regulate tumor immunity and participate in the generation, invasion, migration and drug resistance of PDAC. In prior study, we isolated a polysaccharide from sea urchin-Strongylocentyotus internedius, which was identified as a high molecular weight, highly branched glycogen (MSGA). In this study, we found that MSGA increased the expression of iNOS, IL-6, TNF alpha, IL-12 and triggered macrophage differentiation to the CD86+ M1 phenotype. MSGA-induced M1 macrophages decreased the cell viabilities and induced apoptosis of PDAC cells. When combined with gemcitabine (GEM), MSGA significantly enhanced the pro-apoptotic activity of GEM. Mechanistically, MSGA transformed macrophages to the M1 phenotype through the stimulation of the JAK1/3-STAT1 signaling pathway and the suppression of STAT3 activity. Overall, our research showed that MSGA has profound potential for tumor immunotherapy. And as an "immune stimulator", MSGA could assist GEM in the treatment of PDAC.
WOS关键词TUMOR-ASSOCIATED MACROPHAGES ; IMMUNOSTIMULATORY ACTIVITY ; IMMUNOMODULATORY ACTIVITY ; ANTITUMOR-ACTIVITY ; POLYSACCHARIDE ; MICROENVIRONMENT ; POLARIZATION ; PREVENTS ; TARGETS ; CELLS
资助项目National Natural Science Fundation of China[81872906] ; National Natural Science Fundation of China[42406090] ; China Postdoctoral Science Foundation project[2023M741505]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001545693900001
出版者FRONTIERS MEDIA SA
源URL[http://ir.qdio.ac.cn/handle/337002/202785]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Wu, Ning; Zhang, Quanbin
作者单位1.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Biol Prod, Qingdao, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
5.Shandong Univ, Natl Glycoengn Res Ctr, Qingdao, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Deng, Zhenzhen,Yu, Haoyu,Wu, Ning,et al. A glycogen derived from sea urchin-Strongylocentyotus internedius shifts macrophages to the M1 phenotype and enhances the anti-pancreatic cancer activity of gemcitabine[J]. FRONTIERS IN PHARMACOLOGY,2025,16:12.
APA Deng, Zhenzhen.,Yu, Haoyu.,Wu, Ning.,Wang, Qingchi.,Wang, Jing.,...&Zhang, Quanbin.(2025).A glycogen derived from sea urchin-Strongylocentyotus internedius shifts macrophages to the M1 phenotype and enhances the anti-pancreatic cancer activity of gemcitabine.FRONTIERS IN PHARMACOLOGY,16,12.
MLA Deng, Zhenzhen,et al."A glycogen derived from sea urchin-Strongylocentyotus internedius shifts macrophages to the M1 phenotype and enhances the anti-pancreatic cancer activity of gemcitabine".FRONTIERS IN PHARMACOLOGY 16(2025):12.

入库方式： OAI收割

来源：海洋研究所

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