Synthesis of Aminoalkyl Naphthol Analogues and Their Anti-fungal and Nematicidal Activities
文献类型：期刊论文
| 作者 | Zhang, Qilin1,2,3; Shi, Yanchang1,2; Gao, Kun1,2; Wang, Linsong1,2; Song, Yadong1,2; Wang, Yusen1,2; Li, Pengcheng1,2; Liu, Song1,2; Xing, Ronge1,2; Song, Lin3 |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2025-08-10 |
| 卷号 | 46期号:8页码:11 |
| 关键词 | One pot method Amidoalkyl naphthol Anti-fungal activity Nematicidal activity |
| ISSN号 | 0251-0790 |
| DOI | 10.7503/cjcu20250031 |
| 通讯作者 | Song, Lin(03231@qust.edu.cn) ; Qin, Yukun(ykqin@qdio.ac.cn) |
| 英文摘要 | A series of amino-alkyl naphthol compounds was synthesized through a one-pot three & hybull;component reaction, their antifungal activity against plant pathogenic fungi and nematicidal activity were evaluated. The results showed that compound 8 exhibited about 50% inhibitory activity against Alternaria alternate at concentrations ranging from 200 mu g/mL to 25 mu g/mL, and the inhibitory effect was not significantly correlated with concentration. In vivo antifungal experiments indicated that compound 8 at a concentration of 50 mu g/mL had a therapeutic effect comparable to the positive control pyrimethanil. Additionally, in greenhouse test tube experiments, the synthesized compounds showed significant inhibitory activity against southern root-knot nematodes, with compound 10 significantly reducing the number of galls at a concentration of 10 mu g/mL, achieving an inhibition rate of 90.91%, which is comparable to the positive control fluopyram. In summary, amino-alkyl naphthol compounds, as a new type of pesticide active substance, have potential dual effects of antibiosis and nematicide, and the aforementioned research provides new ideas for the development of environmentally friendly multi-target pesticides. |
| WOS关键词 | HYDROGEN SULFATE |
| 资助项目 | National Natural Science Foundation of China[42076126] ; Shandong Key Research and Development Plan , Major Scientific and Technological Innovation Project , China[2022CXGC020413] ; Qingdao Science and Technology Benefit the People Demonstration Project , China[25-1-5-xdny-7-nsh] ; Central Guidance for Local Scientific and Technological Development Funds, China[2024ZY0039] ; Special Project on Modern Agricultural Industry Technology System , China[CARS -49] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001548599200003 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/203128]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Song, Lin; Qin, Yukun |
| 作者单位 | 1.Qingdao Marine Sci & Technol Ctr, Funct Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China 3.Qingdao Univ Sci & Technol, Bioengn Coll, Qingdao 266042, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Qilin,Shi, Yanchang,Gao, Kun,et al. Synthesis of Aminoalkyl Naphthol Analogues and Their Anti-fungal and Nematicidal Activities[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2025,46(8):11. |
| APA | Zhang, Qilin.,Shi, Yanchang.,Gao, Kun.,Wang, Linsong.,Song, Yadong.,...&Qin, Yukun.(2025).Synthesis of Aminoalkyl Naphthol Analogues and Their Anti-fungal and Nematicidal Activities.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,46(8),11. |
| MLA | Zhang, Qilin,et al."Synthesis of Aminoalkyl Naphthol Analogues and Their Anti-fungal and Nematicidal Activities".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 46.8(2025):11. |
入库方式： OAI收割
来源：海洋研究所
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