An invertebrate NLR recognizes viral nucleic acids and balances the antiviral signaling pathway through interaction with STING and Cyclophilin A
文献类型：期刊论文
| 作者 | Li, Shihao1,2; Li, Xuechun2; Sun, Mingzhe2; Li, Fuhua1,2 |
| 刊名 | PLOS PATHOGENS
 |
| 出版日期 | 2025-08-01 |
| 卷号 | 21期号:8页码:19 |
| ISSN号 | 1553-7366 |
| DOI | 10.1371/journal.ppat.1013433 |
| 通讯作者 | Li, Fuhua(fhli@qdio.ac.cn) |
| 英文摘要 | Intracellular recognition of viral nucleic acids by NLRs and subsequent activation of antiviral immunity are proved to be crucial for host defense against virus infection in vertebrates. However, understanding on these processes is very limited in invertebrates, especially for crustaceans. In the present study, an NLR gene belonging to the NLRC subfamily (LvNLRC) was identified in the Pacific whiteleg shrimp Litopenaeus vannamei and its functions in intracellular recognition to DNA virus and antiviral immunity during WSSV infection were elucidated. LvNLRC possesses an ability to detect DNA viral mimics such as poly(dA:dT) with a dose-dependent manner through its leucine-rich repeat (LRR) domain. The LRR domain also recognizes the partial DNA encoding VP24 of WSSV. LvNLRC could modulate the interferon system-like antiviral response in shrimp through direct interaction between its NACHT domain and LvSTING. Different from the regulatory mechanism in vertebrates, the presence of poly(dA:dT) does not affect the release of STING from the NACHT domain of LvNLRC in shrimp. Interestingly, shrimp Cyclophilin A (LvCypA) can directly interact with the NACHT domain of LvNLRC in a dose-dependent manner in the presence of poly(dA:dT). Furthermore, LvCypA also plays an important role in the regulation of the interferon system-like antiviral immunity in shrimp. The present results provide the first evidence to show that Cyclophilin A can modulate NLR-mediated cytokine-like antiviral immunity in animals. These findings shed light on the roles of NLRs in regulating host innate immunity, contributing valuable insights into this area of study. |
| WOS关键词 | NOD-LIKE RECEPTORS ; NF-KAPPA-B ; INNATE IMMUNE ; INFECTION ; INDUCTION ; FAMILY ; SENSOR ; VIRUS |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDB0730201] ; Strategic Priority Research Program of the Chinese Academy of Sciences[32373168] ; Strategic Priority Research Program of the Chinese Academy of Sciences[31972829] ; Strategic Priority Research Program of the Chinese Academy of Sciences[32102830] ; Strategic Priority Research Program of the Chinese Academy of Sciences[CARS-48] ; Natural Science Foundation of China ; Taishan Scholars Program |
| WOS研究方向 | Microbiology ; Parasitology ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:001552922600001 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/203173]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Li, Fuhua |
| 作者单位 | 1.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, State Key Lab Breeding Biotechnol & Sustainable Aq, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Shihao,Li, Xuechun,Sun, Mingzhe,et al. An invertebrate NLR recognizes viral nucleic acids and balances the antiviral signaling pathway through interaction with STING and Cyclophilin A[J]. PLOS PATHOGENS,2025,21(8):19. |
| APA | Li, Shihao,Li, Xuechun,Sun, Mingzhe,&Li, Fuhua.(2025).An invertebrate NLR recognizes viral nucleic acids and balances the antiviral signaling pathway through interaction with STING and Cyclophilin A.PLOS PATHOGENS,21(8),19. |
| MLA | Li, Shihao,et al."An invertebrate NLR recognizes viral nucleic acids and balances the antiviral signaling pathway through interaction with STING and Cyclophilin A".PLOS PATHOGENS 21.8(2025):19. |
入库方式： OAI收割
来源：海洋研究所
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