Sirenin and bisabolane sesquiterpenoids from two marine isolates of Penicillium chermesinum with anti-osteoporotic activity by modulating NOD-like receptor signaling pathway
文献类型：期刊论文
| 作者 | Liu, Yi-Wei1,2; Li, Xin-Jia4,5; Hu, Xue-Yi2; Li, Xiao-Ming2; Liu, Hui2; Yang, Sui-Qun2; Li, Hong-Lei2; Chen, Xiao-Dan1,2; Jin, Meng4,5; Wang, Bin-Gui1,2,3 |
| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2025-10-01 |
| 卷号 | 165页码:12 |
| 关键词 | Marine-sourced fungi Penicillium chermesinum Sesquiterpenoids Sirenins Anti-osteoporotic activity |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2025.108993 |
| 通讯作者 | Jin, Meng(mjin1985@hotmail.com) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
| 英文摘要 | Nine unreported (chermesirenins A-I, 1-9) and one known (eupenicisirenin C, 10) sirenin sesquiterpenoids as well as two unreported bisabolane-type sesquiterpenoids (chermebisabolins A and B, 11 and 12) were isolated from two isolates of marine-sourced fungal strains Penicillium chermesinum EN-480 and AS-400, which were obtained as endophytic and endozoic fungi from the marine red alga Pterocladiella tenuis and the marine chiton Liolophura japonica, respectively. The sirenin sesquiterpenoids (1-9) featured with unique 6/3 dicyclic ring system while compounds 8 and 9 are nor-sirenin analogs by degrading the C-12 methyl group. Their structures including stereochemical configurations were confirmed through NMR interpretation, ECD analysis, Mosher's method, X-ray crystallographic diffraction, and quantum chemical calculations. The anti-osteoporotic activity evaluation in the zebrafish osteoporosis model revealed that chermesirenin A (1) could significantly alleviate the reduction of bone fluorescence area and fluorescence density in prednisolone-treated zebrafish. Furthermore, compound 1 could down-regulate the expression of the genes associated with prednisolone-induced osteoclastogenesis, ctsk and tnfrsf11b, to improve bone formation status. Exploration on the mechanism through the transcriptomic analysis showed that compound 1 might act on the NOD-like receptor (NLR) signaling pathway involved in inflammatory responses and bone metabolism regulation, which has not been reported among previous investigations on sesquiterpenoids. These results demonstrated that compound 1 deserved further development as a potential candidate towards the therapy of osteoporotic disease. |
| WOS关键词 | ABSOLUTE-CONFIGURATIONS ; ACTIVATION |
| 资助项目 | National Key Research and Development Program of China[2024YFC2815901] ; National Natural Science Foundation of China[W2411036] ; Shandong Postdoctoral Science Foundation[SDCX-ZG-202302023] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001575537000003 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/203443]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Jin, Meng; Wang, Bin-Gui |
| 作者单位 | 1.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 4.Qilu Univ Technol, Biol Inst, Shandong Acad Sci, 28789 East Jingshi Rd, Jinan 250103, Shandong, Peoples R China 5.Shandong First Med Univ & Shandong Acad Med Sci, Inst Brain Sci & Brain Inspired Res, 6699 Qingdao Rd, Jinan 250117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yi-Wei,Li, Xin-Jia,Hu, Xue-Yi,et al. Sirenin and bisabolane sesquiterpenoids from two marine isolates of Penicillium chermesinum with anti-osteoporotic activity by modulating NOD-like receptor signaling pathway[J]. BIOORGANIC CHEMISTRY,2025,165:12. |
| APA | Liu, Yi-Wei.,Li, Xin-Jia.,Hu, Xue-Yi.,Li, Xiao-Ming.,Liu, Hui.,...&Wang, Bin-Gui.(2025).Sirenin and bisabolane sesquiterpenoids from two marine isolates of Penicillium chermesinum with anti-osteoporotic activity by modulating NOD-like receptor signaling pathway.BIOORGANIC CHEMISTRY,165,12. |
| MLA | Liu, Yi-Wei,et al."Sirenin and bisabolane sesquiterpenoids from two marine isolates of Penicillium chermesinum with anti-osteoporotic activity by modulating NOD-like receptor signaling pathway".BIOORGANIC CHEMISTRY 165(2025):12. |
入库方式： OAI收割
来源：海洋研究所
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