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Multi-omics reveal L-DOPA-mediated growth inhibition in turbot (Scophthalmus maximus): Overlooked metabolites for water quality management in recirculating aquaculture systems

文献类型：期刊论文

作者Wang, Xi1,2,3; Song, Xiefa1,2,3; Wang, Yanfeng4,5; Gan, Enlei3; Wang, Zhiyi3; Yuan, Guozi3; Li, Meng1,2,3
刊名AQUACULTURE
出版日期2026-01-15
卷号612页码:9
关键词High-density Metabolomics Transcriptomic Biomarker Oxidative stress
ISSN号0044-8486
DOI10.1016/j.aquaculture.2025.743272
通讯作者Song, Xiefa(yuchuan@ouc.edu.cn) ; Li, Meng(limeng2022@ouc.edu.cn)
英文摘要With the intensification of aquaculture practices, sustainable development under high-density stocking conditions has become a critical challenge. The present study aims to identify the key factors causing growth inhibition in turbot (Scophthalmus maximus) in recirculating aquaculture system (RAS) under high-density conditions through a combined analysis of metabolites in culture water and the transcriptome of gill and liver tissues. Juvenile turbot were reared for 60 days at low density (LD, 4.70 kg/m(2)) and high density (HD, 9.39 kg/m(2)). At Day 60, the HD group showed significantly lower body weight, specific growth rate (SGR), and weight gain rate (WGR) compared to LD (P<0.05). Metabolomic analysis of culture water identified 24 upregulated metabolites in the HD group, with L-DOPA prominently implicated as a potential growth-inhibitory factor. Transcriptomic analysis revealed immune-inflammatory activation in the gills, including glutathione metabolism, MAPK signaling and arachidonic acid metabolism pathway. While liver DEGs related to glutathione metabolic and the p53 signaling pathway, indicating liver damage and apoptosis activation. The study suggests that HD conditions induce the release of L-DOPA, which in turn triggers oxidative stress and inflammation in gills and livers, leading to tissue damage and growth inhibition. This study provides mechanistic insights into density-induced growth inhibition and highlights L-DOPA in water environment as a potential biomarker for aquaculture health monitoring.
WOS关键词STOCKING DENSITY ; STRESS ; L-3,4-DIHYDROXYPHENYLALANINE ; PERFORMANCE ; RESPONSES
资助项目National Key Research and Devel-opment Program of China[2023YFD2400400] ; Taishan Scholar Foundation of Shandong Province[tsqn202306108]
WOS研究方向Fisheries ; Marine & Freshwater Biology
语种英语
WOS记录号WOS:001597553500001
出版者ELSEVIER
源URL[http://ir.qdio.ac.cn/handle/337002/203629]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Song, Xiefa; Li, Meng
作者单位1.Shandong Key Lab Green Mariculture & Smart Fisheri, Qingdao, Peoples R China
2.Ocean Univ China, Coll Fisheries, Key Lab Mariculture, Minist Educ, Qingdao 266001, Peoples R China
3.Ocean Univ China, Coll Fisheries, Marine Organism Water Environm Engn Lab, Qingdao, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
5.Chinese Acad Sci, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xi,Song, Xiefa,Wang, Yanfeng,et al. Multi-omics reveal L-DOPA-mediated growth inhibition in turbot (Scophthalmus maximus): Overlooked metabolites for water quality management in recirculating aquaculture systems[J]. AQUACULTURE,2026,612:9.
APA Wang, Xi.,Song, Xiefa.,Wang, Yanfeng.,Gan, Enlei.,Wang, Zhiyi.,...&Li, Meng.(2026).Multi-omics reveal L-DOPA-mediated growth inhibition in turbot (Scophthalmus maximus): Overlooked metabolites for water quality management in recirculating aquaculture systems.AQUACULTURE,612,9.
MLA Wang, Xi,et al."Multi-omics reveal L-DOPA-mediated growth inhibition in turbot (Scophthalmus maximus): Overlooked metabolites for water quality management in recirculating aquaculture systems".AQUACULTURE 612(2026):9.

入库方式： OAI收割

来源：海洋研究所

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