A chloride-mediated low-energy pathway for selective 3A5AF production from N-acetylglucosamine via solubility-tailored catalysis
文献类型：期刊论文
| 作者 | Dong, Chengna1,3; Gao, Kun1; Song, Yadong1; Xing, Ronge1,2; Yu, Huahua1,2; Liu, Song1,2; Li, Pengcheng1,2; Qin, Yukun1,2 |
| 刊名 | MOLECULAR CATALYSIS
 |
| 出版日期 | 2025-12-01 |
| 卷号 | 587页码:12 |
| 关键词 | Chitin biomass Chloride salts Solubility Solubilization promotion 3A5AF |
| ISSN号 | 2468-8231 |
| DOI | 10.1016/j.mcat.2025.115498 |
| 通讯作者 | Qin, Yukun(ykqin@qdio.ac.cn) |
| 英文摘要 | The synthesis of high-value organic nitrogen compounds from renewable chitin biomass presents significant environmental advantages by reducing reliance on fossil resources. Among these compounds, 3-acetamido-5-acetylfuran (3A5AF) has emerged as a versatile nitrogen-containing platform molecule, attracting extensive research attention. However, existing studies indicate that 3A5AF formation in polar aprotic solvents (e.g., N, N-dimethylacetamide, DMA) typically requires harsh conditions (>150 degrees C), likely due to limited catalyst and substrate solubility at lower temperatures. To address this challenge, this study employed anhydrous magnesium chloride (MgCl2) as a catalyst-selected for its Cl- supply capacity based on solubility tests-combined with ammonium salts as additives to establish a weakly acidic reaction environment. The catalytic system enabled efficient 3A5AF conversion under milder conditions, achieving a remarkable yield of 60.3% at 140 degrees C. This research provides a low-energy, economic and easy-to-industrialize technological path for the preparation of nitrogen-containing fine chemicals from chitin biomass. |
| WOS关键词 | ACETYL-D-GLUCOSAMINE ; CHITIN ; CONVERSION |
| 资助项目 | National Natural Science Foundation of China[42076126] ; Shandong Key R D Plan ; Major Scientific and Technological Innovation Project[2022CXGC020413] ; Shandong Provincial Natural Science Foundation[ZR2025MS456] ; Qingdao Science and Technology Benefit the People Demonstration Project[25-1-5-xdny-7-nsh] ; Central guidance for local scientific and technological development funds[2024ZY0039] ; Earmarked Fund for Modern Agro-industry Technology Research System[CARS-49] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001616721800001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/203755]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Qin, Yukun |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Lab Expt Marine Biol, Qingdao 266000, Peoples R China 2.Qingdao Marine Sci & Technol Ctr Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Chengna,Gao, Kun,Song, Yadong,et al. A chloride-mediated low-energy pathway for selective 3A5AF production from N-acetylglucosamine via solubility-tailored catalysis[J]. MOLECULAR CATALYSIS,2025,587:12. |
| APA | Dong, Chengna.,Gao, Kun.,Song, Yadong.,Xing, Ronge.,Yu, Huahua.,...&Qin, Yukun.(2025).A chloride-mediated low-energy pathway for selective 3A5AF production from N-acetylglucosamine via solubility-tailored catalysis.MOLECULAR CATALYSIS,587,12. |
| MLA | Dong, Chengna,et al."A chloride-mediated low-energy pathway for selective 3A5AF production from N-acetylglucosamine via solubility-tailored catalysis".MOLECULAR CATALYSIS 587(2025):12. |
入库方式： OAI收割
来源：海洋研究所
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