Genome-wide association analysis provides genetic insights into variation of nutritional quality traits in sea cucumber Apostichopus japonicus
文献类型：期刊论文
| 作者 | Zhao, Hongyuan2,3,4,5; Huo, Da2,3,4; Cui, Wei2,3,4; Jiang, Chunxi2,3,4; Liu, Shilin2,3,4; Rasoamananto, Irene1; Zhang, Libin2,3,4; Sun, Lina2,3,4 |
| 刊名 | JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| 出版日期 | 2025-05-22 |
| 页码 | 14 |
| 关键词 | |
| ISSN号 | 2096-5508 |
| DOI | 10.1007/s00343-025-4274-2 |
| 通讯作者 | Sun, Lina(sunlina@qdio.ac.cn) |
| 英文摘要 | Sea cucumber Apostichopus japonicus is a crucial aquatic species known for its nutritional value. However, the genetic basis and regulatory mechanisms underlying its nutritional quality remain underexplored. This study investigates the nutritional quality of A. japonicus from different geographical regions and identifies genetic markers associated with these traits through a genome-wide association study (GWAS). We observed significant regional variations in the nutritional content of A. japonicus. Samples collected from Nanhuangcheng Island displayed the highest levels of saponins, whereas those from Laizhou exhibited the highest concentrations of glycosaminoglycans. Lingshan Island samples were the richest in amino acids, while samples from Rizhao contained the highest levels of polyunsaturated fatty acids. Through GWAS, 265 candidate genes and related single nucleotide polymorphisms (SNPs) were identified as being significantly associated with essential nutritional traits, including genes like ubiquitin domain-containing protein 1 (UBTD1), inactive pancreatic lipase-related protein 1, protein arginine N-methyltransferase 5 (PRMT5) and GDP-fucose protein O-fucosyltransferase 1 (POFUT1). This study advanced our knowledge of the genetic mechanisms underlying the nutritional quality of A. japonicus. The genetic markers identified herein offer crucial insights for breeding initiatives aimed at optimizing the nutritional profile of sea cucumbers. |
| WOS关键词 | SULFATED GLYCOSAMINOGLYCANS ; PROXIMATE COMPOSITION ; CHEMICAL-COMPOSITION ; GROWTH ; DISCRIMINATION ; POPULATION ; COMPONENT ; GAG ; RED ; DNA |
| 资助项目 | Key Research and Development Program of Shandong[2021LZGC029] ; Key Research and Development Program of Shandong[2023LZGC019] ; National Natural Science Foundation China[42076093] ; Special Funds for the Central Government to Guide Local Science and Technology Development[YDZX2023043] ; Taishan Scholars Program[tsqn202306279] |
| WOS研究方向 | Marine & Freshwater Biology ; Oceanography |
| 语种 | 英语 |
| WOS记录号 | WOS:001492838100001 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/202070]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Sun, Lina |
| 作者单位 | 1.Univ Toliara, Inst Halieut & Sci Marines IHSM, POB 141, Toliara 601, Madagascar 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 5.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Hongyuan,Huo, Da,Cui, Wei,et al. Genome-wide association analysis provides genetic insights into variation of nutritional quality traits in sea cucumber Apostichopus japonicus[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2025:14. |
| APA | Zhao, Hongyuan.,Huo, Da.,Cui, Wei.,Jiang, Chunxi.,Liu, Shilin.,...&Sun, Lina.(2025).Genome-wide association analysis provides genetic insights into variation of nutritional quality traits in sea cucumber Apostichopus japonicus.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,14. |
| MLA | Zhao, Hongyuan,et al."Genome-wide association analysis provides genetic insights into variation of nutritional quality traits in sea cucumber Apostichopus japonicus".JOURNAL OF OCEANOLOGY AND LIMNOLOGY (2025):14. |
入库方式： OAI收割
来源：海洋研究所
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