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Genomic and phylogenetic analyses of the domoic acid biosynthesis genes in the benthic diatom Nitzschia navis-varingica (Bacillariophyceae)

文献类型：期刊论文

作者Cui, Zongmei4,5,7; Wang, Hui4,5,6,7; Lim, Po Teen1; Tan, Suh Nih2; Kotaki, Yuichi3; Leaw, Chui Pin1; Chen, Nansheng4,5,7
刊名HARMFUL ALGAE
出版日期2025-09-01
卷号148页码:9
关键词Domoic acid Harmful algal bloom Neurotoxin Nitzschia navis-varingica Pseudo-nitzschia Toxin biosynthesis genes Comparative genomics
ISSN号1568-9883
DOI10.1016/j.hal.2025.102905
通讯作者Leaw, Chui Pin(cpleaw@um.edu.my) ; Chen, Nansheng(chenn@qdio.ac.cn)
英文摘要Through genome sequencing and comparative genomic analysis, candidate genes involved in the biosynthesis of domoic acid (DA) in the benthic diatom Nitzschia navis-varingica were identified. Orthologs of DA biosynthesis genes (dabA, dabB, dabC, and dabD), originally identified in Pseudo-nitzschia species, were detected in N. navisvaringica strains. However, due to the draft level of our genomes, the tandem gene cluster organization present in the Pseudo-nitzschia species cannot be determined in N. navis-varingica strains. In addition, two copies of dabC were found in N. navis-varingica strains, suggesting potential functional significance in the biosynthesis of DA and its isoforms. The identification of dab genes in N. navis-varingica provides a foundation for further studies on the origin, evolution, and transcriptional regulations of DA biosynthesis in this benthic diatom.
WOS关键词PSEUDO-NITZSCHIA ; VISUALIZATION ; MORPHOLOGY ; SHELLFISH ; SEQUENCE ; TOXIN ; NOV
资助项目Natural Science Foundation of China[42176162] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB42000000] ; Malaysian Ministry of Higher Education Malaysia through the Higher Center of Excellence Fund[HICoE IOES-2023B] ; Chinese Academy of Sciences President's International Fellowship Initiative[2025PVB0061]
WOS研究方向Marine & Freshwater Biology
语种英语
WOS记录号WOS:001502991900001
出版者ELSEVIER
源URL[http://ir.qdio.ac.cn/handle/337002/202172]  
专题海洋研究所_海洋生态与环境科学重点实验室
通讯作者Leaw, Chui Pin; Chen, Nansheng
作者单位1.Univ Malaya, Inst Ocean & Earth Sci, Bachok Marine Res Stn, Bachok 16310, Kelantan, Malaysia
2.Xiamen Univ Malaysia, China ASEAN Coll Marine Sci, Sepang 43900, Selangor, Malaysia
3.Tohoku Univ, Grad Sch Agr Sci, 468-1 Aramaki Aza Aoba, Aoba Ku, Sendai 9808572, Japan
4.Qingdao Marine Sci & Technol Ctr, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China
5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
6.Univ Chinese Acad Sci, Coll Marine Sci, Beijing 100039, Peoples R China
7.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Cui, Zongmei,Wang, Hui,Lim, Po Teen,et al. Genomic and phylogenetic analyses of the domoic acid biosynthesis genes in the benthic diatom Nitzschia navis-varingica (Bacillariophyceae)[J]. HARMFUL ALGAE,2025,148:9.
APA Cui, Zongmei.,Wang, Hui.,Lim, Po Teen.,Tan, Suh Nih.,Kotaki, Yuichi.,...&Chen, Nansheng.(2025).Genomic and phylogenetic analyses of the domoic acid biosynthesis genes in the benthic diatom Nitzschia navis-varingica (Bacillariophyceae).HARMFUL ALGAE,148,9.
MLA Cui, Zongmei,et al."Genomic and phylogenetic analyses of the domoic acid biosynthesis genes in the benthic diatom Nitzschia navis-varingica (Bacillariophyceae)".HARMFUL ALGAE 148(2025):9.

入库方式： OAI收割

来源：海洋研究所

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