A deep-sea hydrothermal vent worm detoxifies arsenic and sulfur by intracellular biomineralization of orpiment (As2S3)
文献类型：期刊论文
| 作者 | Wang, Hao2,3; Cao, Lei2; Zhang, Huan2; Zhong, Zhaoshan2; Zhou, Li2; Lian, Chao2; Wang, Xiaocheng4; Chen, Hao2; Wang, Minxiao2; Zhang, Xin1 |
| 刊名 | PLOS BIOLOGY
 |
| 出版日期 | 2025-08-27 |
| 卷号 | 23期号:8页码:25 |
| ISSN号 | 1544-9173 |
| DOI | 10.1371/journal.pbio.3003291 |
| 通讯作者 | Li, Chaolun(lcl@qdio.ac.cn) |
| 英文摘要 | The alvinellid worm Paralvinella hessleri is the only animal that colonizes the hottest part of deep-sea hydrothermal vents in the west pacific. We found P. hessleri accumulates exceptionally high level of toxic element arsenic (>1% of wet weight) and tolerated elevated concentrations hydrogen sulphide. Using advanced microscopy, elementary analysis, and genomics and proteomics approaches, we identified a previously unrecognized arsenic-sulfide biomineralization process in P. hessleri. Our data suggest that arsenic accumulates within epithelial cell granules, where it likely reacts with sulphide diffused inward from the hydrothermal vent fluid, resulting in the intracellular formation of orpiment (As2S3) minerals. In this "fighting poison with poison" manner, the highly toxic arsenic and sulphide were simultaneously detoxified in the form of orpiment minerals within the intracellular granules of the single layer of epithelial cells. This process represents a remarkable adaptation to extreme chemical environments. Our study provides new insights into understanding animals' environment adaptation mechanisms and the diversity and plasticity of biomineralization. |
| WOS关键词 | EAST PACIFIC RISE ; ALVINELLA-POMPEJANA ; RIFTIA-PACHYPTILA ; HYDROGEN-SULFIDE ; ARENICOLA-MARINA ; POLYCHAETA ; HEMOGLOBIN ; ECOLOGY ; METABOLISM ; BINDING |
| 资助项目 | Natural Science Foundation of China[42030407] ; Natural Science Foundation of China[LSKJ202203104] ; Science and Technology Innovation Project of Laoshan Laboratory[2018YFC0310702] ; National Key RandD Program of China[42221005] ; NSFC Innovative Group Grant |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001559419700002 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/203245]  |
| 专题 | 海洋研究所_海洋地质与环境重点实验室 |
| 通讯作者 | Li, Chaolun |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Geol & Environm, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Deep Sea Res, Qingdao, Peoples R China 3.Qingdao Marine Sci & Technol Ctr, Laoshan Lab, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Natl Marine Environm Monitoring Ctr, Dalian, Peoples R China 5.Chinese Acad Sci, South China Sea Inst Oceanol, Guangzhou, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hao,Cao, Lei,Zhang, Huan,et al. A deep-sea hydrothermal vent worm detoxifies arsenic and sulfur by intracellular biomineralization of orpiment (As2S3)[J]. PLOS BIOLOGY,2025,23(8):25. |
| APA | Wang, Hao.,Cao, Lei.,Zhang, Huan.,Zhong, Zhaoshan.,Zhou, Li.,...&Li, Chaolun.(2025).A deep-sea hydrothermal vent worm detoxifies arsenic and sulfur by intracellular biomineralization of orpiment (As2S3).PLOS BIOLOGY,23(8),25. |
| MLA | Wang, Hao,et al."A deep-sea hydrothermal vent worm detoxifies arsenic and sulfur by intracellular biomineralization of orpiment (As2S3)".PLOS BIOLOGY 23.8(2025):25. |
入库方式： OAI收割
来源：海洋研究所
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