RNA-sequencing Analysis of Hybrid Females Reveals a Dominance of Expression of Alleles From Outcrossing Species Over Those From Selfing Species
文献类型：期刊论文
| 作者 | Shao, Yanwen2; Zhang, Yiwen2; Ren, Xiaoliang4; Ho, Vincy Wing Sze3; Bi, Yu2; Zhao, Zhongying5; Li, Runsheng1,2,6 |
| 刊名 | GENOME BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2025-06-01 |
| 卷号 | 17期号:6页码:20 |
| 关键词 | C. briggsae and C. nigoni hybrid incompatibility genetic asymmetry nuclear-cytoplasmic incompatibility interspecies |
| ISSN号 | 1759-6653 |
| DOI | 10.1093/gbe/evaf098 |
| 通讯作者 | Zhao, Zhongying(zyzhao@hkbu.edu.hk) ; Li, Runsheng(runsheng.li@cityu.edu.hk) |
| 英文摘要 | The sister species Caenorhabditis briggsae and Caenorhabditis nigoni are the first Caenorhabditis nematode pair known to produce viable F1 hybrids, making them an ideal model for speciation study. Male F1 hybrids are lethal or sterile depending on the parent of origin, while F1 females, though viable, exhibit distinct phenotypes in fecundity and viability. Besides, both female hybrids could mate with C. nigoni males to produce viable progeny but experience hybrid breakdown when crossed with C. briggsae males. The molecular mechanisms driving these phenotype variations in F1 females remain unknown. Here, we analyzed the transcriptomes of F1 female hybrids from both crossing directions to examine whether a parent-specific haplotype dominates gene expression in the hybrids and to explore the mechanisms underlying the distinct phenotypes. We showed that in female hybrids from both directions, the C. nigoni haplotype was more abundantly expressed and maintained the parental expression patterns better than that of C. briggsae. We also observed an upregulation of female-biased genes in the C. nigoni haplotype of F1 females, which may explain their compatibility with C. nigoni males for producing viable progeny, suggesting a haplotype-specific influence on female reproductive traits. Our mitochondrial gene analysis suggested a nuclear-cytoplasmic incompatibility marked by cis-dominated expression patterns of mitochondrial genes, which may contribute to the reduced viability in F1 females. This research provides insights into the expression pattern of interspecies F1 female hybrids and the mechanisms underlying nonlethal hybrid incompatibility defects. |
| WOS关键词 | GENE-EXPRESSION ; CAENORHABDITIS-BRIGGSAE ; MITOCHONDRIAL GENOME ; HALDANES RULE ; REGULATORY DIVERGENCE ; X-CHROMOSOME ; EVOLUTION ; CIS ; INCOMPATIBILITY ; MECHANISMS |
| 资助项目 | Hetao Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone Shenzhen Park Project[HZQB-KCZYZ-2021017] ; Early Career Scheme from the Hong Kong Research Grant Council[CityU 21100521] ; Hong Kong Health and Medical Research Fund[08194126] ; New Research Initiatives Support from City University of Hong Kong[9610497] |
| WOS研究方向 | Evolutionary Biology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:001502830600001 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/202220]  |
| 专题 | 海洋研究所_海洋生物分类与系统演化实验室 |
| 通讯作者 | Zhao, Zhongying; Li, Runsheng |
| 作者单位 | 1.City Univ Hong Kong, Tung Biomed Sci Ctr, Hong Kong, Peoples R China 2.City Univ Hong Kong, Jockey Club Coll Vet Med & Life Sci, Dept Infect Dis & Publ Hlth, Hong Kong, Peoples R China 3.Chinese Univ Hong Kong, Dept Surg, Hong Kong, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Dept Marine Organism Taxon & Phylogeny, Qingdao 266071, Peoples R China 5.Hong Kong Baptist Univ, Dept Biol, Hong Kong, Peoples R China 6.City Univ Hong Kong, Shenzhen Futian Res Inst, Dept Precis Diagnost & Therapeut Technol, Shenzhen 518057, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shao, Yanwen,Zhang, Yiwen,Ren, Xiaoliang,et al. RNA-sequencing Analysis of Hybrid Females Reveals a Dominance of Expression of Alleles From Outcrossing Species Over Those From Selfing Species[J]. GENOME BIOLOGY AND EVOLUTION,2025,17(6):20. |
| APA | Shao, Yanwen.,Zhang, Yiwen.,Ren, Xiaoliang.,Ho, Vincy Wing Sze.,Bi, Yu.,...&Li, Runsheng.(2025).RNA-sequencing Analysis of Hybrid Females Reveals a Dominance of Expression of Alleles From Outcrossing Species Over Those From Selfing Species.GENOME BIOLOGY AND EVOLUTION,17(6),20. |
| MLA | Shao, Yanwen,et al."RNA-sequencing Analysis of Hybrid Females Reveals a Dominance of Expression of Alleles From Outcrossing Species Over Those From Selfing Species".GENOME BIOLOGY AND EVOLUTION 17.6(2025):20. |
入库方式： OAI收割
来源：海洋研究所
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