A Review of Fluorescent pH Probes: Ratiometric Strategies, Extreme pH Sensing, and Multifunctional Utility
文献类型：期刊论文
| 作者 | Xu, Weiqiao1,2; Ma, Zhenting1,2; Tian, Qixin2; Chen, Yuanqing2; Jiang, Qiumei2; Fan, Liang1 |
| 刊名 | CHEMOSENSORS
 |
| 出版日期 | 2025-08-02 |
| 卷号 | 13期号:8页码:21 |
| 关键词 | fluorescent pH probes photophysical mechanisms acidic/alkaline sensing |
| DOI | 10.3390/chemosensors13080280 |
| 通讯作者 | Fan, Liang(fanl@qdio.ac.cn) |
| 英文摘要 | pH is a critical parameter requiring precise monitoring across scientific, industrial, and biological domains. Fluorescent pH probes offer a powerful alternative to traditional methods (e.g., electrodes, indicators), overcoming limitations in miniaturization, long-term stability, and electromagnetic interference. By utilizing photophysical mechanisms-including intramolecular charge transfer (ICT), photoinduced electron transfer (PET), and fluorescence resonance energy transfer (FRET)-these probes enable high-sensitivity, reusable, and biocompatible sensing. This review systematically details recent advances, categorizing probes by operational pH range: strongly acidic (0-3), weakly acidic (3-7), strongly alkaline (>12), weakly alkaline (7-11), near-neutral (6-8), and wide-dynamic range. Innovations such as ratiometric detection, organelle-specific targeting (lysosomes, mitochondria), smartphone colorimetry, and dual-analyte response (e.g., pH + Al3+/CN-) are highlighted. Applications span real-time cellular imaging (HeLa cells, zebrafish, mice), food quality assessment, environmental monitoring, and industrial diagnostics (e.g., concrete pH). Persistent challenges include extreme-pH sensing (notably alkalinity), photobleaching, dye leakage, and environmental resilience. Future research should prioritize broadening functional pH ranges, enhancing probe stability, and developing wide-range sensing strategies to advance deployment in commercial and industrial online monitoring platforms. |
| WOS关键词 | SENSOR ; RUTHENIUM ; DESIGN ; METER |
| 资助项目 | Shandong Excellent Youth Science Foundation Program ; Guangxi Science and Technology Program[Guike AA23026007] ; Taishan Scholars Program ; [2023HWYQ-100] |
| WOS研究方向 | Chemistry ; Electrochemistry ; Instruments & Instrumentation |
| 语种 | 英语 |
| WOS记录号 | WOS:001559575700001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/203218]  |
| 专题 | 海洋研究所_海洋腐蚀与防护研究发展中心 |
| 通讯作者 | Fan, Liang |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Adv Marine Mat, Qingdao 266071, Peoples R China 2.Guangxi Acad Sci, Guangxi Acad Marine Sci, Guangxi Key Lab Marine Environm Sci, Nanning 530007, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Weiqiao,Ma, Zhenting,Tian, Qixin,et al. A Review of Fluorescent pH Probes: Ratiometric Strategies, Extreme pH Sensing, and Multifunctional Utility[J]. CHEMOSENSORS,2025,13(8):21. |
| APA | Xu, Weiqiao,Ma, Zhenting,Tian, Qixin,Chen, Yuanqing,Jiang, Qiumei,&Fan, Liang.(2025).A Review of Fluorescent pH Probes: Ratiometric Strategies, Extreme pH Sensing, and Multifunctional Utility.CHEMOSENSORS,13(8),21. |
| MLA | Xu, Weiqiao,et al."A Review of Fluorescent pH Probes: Ratiometric Strategies, Extreme pH Sensing, and Multifunctional Utility".CHEMOSENSORS 13.8(2025):21. |
入库方式： OAI收割
来源：海洋研究所
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