Biodegradable cellulose scaffolds embedding kartogenin-loaded microspheres for cartilage regeneration
文献类型：期刊论文
| 作者 | Yu, Xinding1,2; Wang, Jian3; Zhou, Shenglai4; Pan, Peng1,2; Chen, Tiantian1,2; Wang, Xi5; Liu, Wentao1,2 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2025-05-01 |
| 卷号 | 306页码:11 |
| 关键词 | Cartilage defect Microspheres Composite scaffold |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2025.141344 |
| 通讯作者 | Liu, Wentao(wtliu@imr.ac.cn) |
| 英文摘要 | Due to the extreme difficulty of cartilage, we endeavored to fabricate a novel biodegradable scaffold using natural polysaccharide cellulose and poly(lactic-co-glycolic acid) (PLGA) microspheres incorporating controllably released the cartilage inducer kartogenin (KGN) for enhancing regenerative healing in cartilage tissue. Initially, to facilitate the loading of KGN, PLGA/KGN microspheres were fabricated using the solvent volatilization method. These microspheres exhibited high sphericity, with particle sizes diminishing from 12.11 to 3.27 mu m as the emulsification rate increased. Demonstrating adequate encapsulation efficiency, the microspheres enabled controlled drug release, positively influencing cell migration and recruitment. Subsequently, a biodegradable cellulose composite scaffold loaded with PLGA/KGN microspheres was prepared using the freeze-drying method. Compared with pure MCC scaffolds, composite scaffolds had a lower degradation rate, and the incorporation of microspheres promoted cell proliferation and significantly elevated expression of cartilage-related specific genes. In a rat cartilage defect model, it was further demonstrated that the composite scaffold combined with stem cell implantation achieved an optimal repair effect, characterized by vigorous extracellular matrix secretion and increased maturity of the regenerated cartilage tissues, suggesting potential clinical application value as a novel articular cartilage repair product in the future. |
| 资助项目 | Applied Basic Research Programs of Liaoning Province[2022JH2/101300104] ; Interdisciplinary Convergence Foundation of Medical Engineering of Natural Science Foundation of Liaoning Province[2022-YGJC-02] ; Shenyang Na-tional Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences[E01SL607] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001436751900001 |
| 出版者 | ELSEVIER |
| 资助机构 | Applied Basic Research Programs of Liaoning Province ; Interdisciplinary Convergence Foundation of Medical Engineering of Natural Science Foundation of Liaoning Province ; Shenyang Na-tional Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Liu, Wentao |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Liaoning, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China 3.Jinzhou Med Univ, Dept Orthoped, Affiliated Hosp 1, Jinzhou 121000, Peoples R China 4.China Med Univ, China Lab Anim Ctr, Shenyang 110001, Liaoning, Peoples R China 5.China Med Univ, Sch & Hosp Stomatol, Dept Emergency & Oral Med, Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Xinding,Wang, Jian,Zhou, Shenglai,et al. Biodegradable cellulose scaffolds embedding kartogenin-loaded microspheres for cartilage regeneration[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2025,306:11. |
| APA | Yu, Xinding.,Wang, Jian.,Zhou, Shenglai.,Pan, Peng.,Chen, Tiantian.,...&Liu, Wentao.(2025).Biodegradable cellulose scaffolds embedding kartogenin-loaded microspheres for cartilage regeneration.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,306,11. |
| MLA | Yu, Xinding,et al."Biodegradable cellulose scaffolds embedding kartogenin-loaded microspheres for cartilage regeneration".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 306(2025):11. |
入库方式： OAI收割
来源：金属研究所
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