Cu-containing stainless steel target quorum sensing to interfere with bacterial motility
文献类型：期刊论文
| 作者 | Liu, Min1,2; Zhang, Xinrui2; Yang, Chunguang2,3 |
| 刊名 | WATER RESEARCH
 |
| 出版日期 | 2025-04-15 |
| 卷号 | 274页码:13 |
| 关键词 | Cu-containing stainless steel Quorum sensing Motility Biofilm Reactive oxygen species |
| ISSN号 | 0043-1354 |
| DOI | 10.1016/j.watres.2024.123044 |
| 通讯作者 | Zhang, Xinrui(xrzhang16s@imr.ac.cn) ; Yang, Chunguang(cgyang@imr.ac.cn) |
| 英文摘要 | Biofilms have been known to cause contamination of drinking water and reduce the efficiency of wastewater treatment. Despite there are many strategies about reducing surface adhesion or killing bacteria, stubborn biofilms are difficult to eradicate completely and still cause continuous contamination because of the difficulty to find comprehensive and effective targets. Here, we identify a new role for quorum sensing (QS) in regulating bacterial motility during biofilm development. We proposed a mechanism of quorum quenching (QQ) by Cucontaining stainless steel (SS), aiming to interfere bacterial motility which associated with surface-attached bacteria self-organizing into microcolonies in early biofilm and the growth and extension of developmental biofilm. A parallel cell-tracking process was conducted to extract the motility history of multiple cells on a newly colonized surface and movement trajectories of biofilm maturation in situ real-time. Results showed Cucontaining SS enhanced bacterial motility of early biofilm, therefore weakening the colonization. Moreover, the development of bacterial community self-organization was retarded by reducing "trajectory cross-over" during the mature stage. Using engineered strains with deleted QS signal, we confirmed QS played a key role in determining bacterial motility. The QQ by Cu-containing SS ultimately guided bacterial motility towards an unfavorable trend for biofilm development. |
| 资助项目 | National Natural Science Foundation of China[52301307] ; National Natural Science Foundation of China[52171242] ; Peak Climbing Project of Foshan Hospital of Traditional Chinese Medicine[202000206] ; Technology Innovation of Foshan City[2020001004942] ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province[2022-YGJC-49] |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology ; Water Resources |
| 语种 | 英语 |
| WOS记录号 | WOS:001419527000001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 资助机构 | National Natural Science Foundation of China ; Peak Climbing Project of Foshan Hospital of Traditional Chinese Medicine ; Technology Innovation of Foshan City ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Zhang, Xinrui; Yang, Chunguang |
| 作者单位 | 1.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.Shenyang Clin Med Res Ctr Orthodont Dis, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Min,Zhang, Xinrui,Yang, Chunguang. Cu-containing stainless steel target quorum sensing to interfere with bacterial motility[J]. WATER RESEARCH,2025,274:13. |
| APA | Liu, Min,Zhang, Xinrui,&Yang, Chunguang.(2025).Cu-containing stainless steel target quorum sensing to interfere with bacterial motility.WATER RESEARCH,274,13. |
| MLA | Liu, Min,et al."Cu-containing stainless steel target quorum sensing to interfere with bacterial motility".WATER RESEARCH 274(2025):13. |
入库方式： OAI收割
来源：金属研究所
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