In vitro degradation and in vivo osteogenesis of Mg-Zn-Nd-Zr/HA composites prepared by friction stir processing
文献类型：期刊论文
| 作者 | Zhang, Wen1,2; Lu, Jiarui3; Tan, Lili2; Ni, Dingrui2; Zhang, Ran3; Zhou, Qing3; Yang, Ke2; Wang, Qiang3 |
| 刊名 | JOURNAL OF MAGNESIUM AND ALLOYS
 |
| 出版日期 | 2024-12-01 |
| 卷号 | 12期号:12页码:4937-4952 |
| 关键词 | Biodegradable Mg-based composite Friction stir processing Hydroxyapatite Osteogenesis In vivo biodegradation |
| ISSN号 | 2213-9567 |
| DOI | 10.1016/j.jma.2023.09.030 |
| 通讯作者 | Tan, Lili(lltan@imr.ac.cn) ; Ni, Dingrui(drni@imr.ac.cn) ; Wang, Qiang(mfqwang@cmu.edu.cn) |
| 英文摘要 | Biodegradable magnesium-matrix composites (BMMCs) added with bone-like compounds such as hydroxyapatite (HA) have promising orthopedic application potential, but the in vivo results of BMMCs are insufficient, and the difference between in vitro and in vivo are not clarified. In this work, Mg-Zn-Nd-Zr/(10/15/20wt%) HA (Ca10(PO4)6OH2) composites were prepared through friction stirring processing (FSP). It was found that corrosion rate of the composites increased with increase of the HA content, where the corrosion rate from hydrogen evolution of the Mg/10wt% HA was about 0.107 mm/y, showing better corrosion resistance compared with other BMMCs, and the agglomeration of HA powders significantly aggravated the localized corrosion. The ALP specific activity of the MC3T3-E1 cells cultured for 14 days with Mg/10wt% HA (2.12 IU/mg) was higher than that of the matrix (1.85 IU/mg), but there was no difference with the FSP group (2.13 IU/mg). In the early implantation of the rabbit femur, bone volume fraction (BV/TV) of Mg/10wt% HA was 10.69, which was higher than that of the FSP group (6.35). The histological staining showed that the Mg/10wt% HA implant was surrounded by more trabecular bone tissue, exhibiting better osteoinductive regeneration. The Mg-Zn-Nd-Zr/HA composites exhibit higher osteogenic activity in vivo differently from in vitro osteogenic expression. (c) 2023 Chongqing University. Publishing services provided by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/) Peer review under responsibility of Chongqing University |
| 资助项目 | National Natural Science Foundation of China[51971222] ; STS program[20201600200042] ; Basic applied research program of Liaoning Province of China[2022020347-JH2/1013] |
| WOS研究方向 | Metallurgy & Metallurgical Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001419760000001 |
| 出版者 | KEAI PUBLISHING LTD |
| 资助机构 | National Natural Science Foundation of China ; STS program ; Basic applied research program of Liaoning Province of China |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Tan, Lili; Ni, Dingrui; Wang, Qiang |
| 作者单位 | 1.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang 110001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Wen,Lu, Jiarui,Tan, Lili,et al. In vitro degradation and in vivo osteogenesis of Mg-Zn-Nd-Zr/HA composites prepared by friction stir processing[J]. JOURNAL OF MAGNESIUM AND ALLOYS,2024,12(12):4937-4952. |
| APA | Zhang, Wen.,Lu, Jiarui.,Tan, Lili.,Ni, Dingrui.,Zhang, Ran.,...&Wang, Qiang.(2024).In vitro degradation and in vivo osteogenesis of Mg-Zn-Nd-Zr/HA composites prepared by friction stir processing.JOURNAL OF MAGNESIUM AND ALLOYS,12(12),4937-4952. |
| MLA | Zhang, Wen,et al."In vitro degradation and in vivo osteogenesis of Mg-Zn-Nd-Zr/HA composites prepared by friction stir processing".JOURNAL OF MAGNESIUM AND ALLOYS 12.12(2024):4937-4952. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。