Unveiling the effect of bovine serum albumin on the packaging performance of medical silicone rubber coating for implantable electronic devices
文献类型：期刊论文
| 作者 | Qi, Shiqian1,2; Yan, Hui1,2; Tang, Ao1; Li, Ying1,3 |
| 刊名 | PROGRESS IN ORGANIC COATINGS
 |
| 出版日期 | 2025-04-01 |
| 卷号 | 201页码:13 |
| 关键词 | Organic coatings BSA adsorption Implantable electronic devices Packaging performance |
| ISSN号 | 0300-9440 |
| DOI | 10.1016/j.porgcoat.2025.109108 |
| 通讯作者 | Tang, Ao(a.tang@imr.ac.cn) ; Li, Ying(liying@imr.ac.cn) |
| 英文摘要 | Silicone rubber encapsulation materials utilized in implantable electronic devices must withstand a complex biofluidic environment and incorporate a diverse array of inorganic and organic components. Nevertheless, the impact of proteins on the reliability of these encapsulation materials has not been extensively investigated. This study presents a thorough examination of the mechanisms through which proteins influence the performance of silicone rubber encapsulation materials. Initially, it was observed that bovine serum albumin (BSA) adsorbs in an elliptical particulate form, a process facilitated by the presence of peptide bonds (-CO-NH-) and alpha-helical structures, which are functional groups inherent to medical silicone rubber coatings. Additionally, the geometric dimensions of BSA are marginally larger than the microscopic pores of the coating, effectively obstructing water passage through the silicone rubber by blocking these pores. This blockage is crucial for enhancing the encapsulation properties of the coatings, as it significantly inhibits water transport. However, as the coating undergoes cracking, its encapsulation capacity is compromised, allowing for the diffusion of BSA to the T2 copper surface. At this juncture, BSA occupies the adsorption sites of the cathodic reactant O2, thereby effectively inhibiting the corrosion of the metal. |
| 资助项目 | National Natural Science Foun-dation of China[52271079] ; National Natural Science Foun-dation of China[51871227] |
| WOS研究方向 | Chemistry ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001424868400001 |
| 出版者 | ELSEVIER SCIENCE SA |
| 资助机构 | National Natural Science Foun-dation of China |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Tang, Ao; Li, Ying |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 3.Northeastern Univ, Shenyang Natl Lab Mat Sci, 3-11 Wenhua Rd, Shenyang 110819, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Shiqian,Yan, Hui,Tang, Ao,et al. Unveiling the effect of bovine serum albumin on the packaging performance of medical silicone rubber coating for implantable electronic devices[J]. PROGRESS IN ORGANIC COATINGS,2025,201:13. |
| APA | Qi, Shiqian,Yan, Hui,Tang, Ao,&Li, Ying.(2025).Unveiling the effect of bovine serum albumin on the packaging performance of medical silicone rubber coating for implantable electronic devices.PROGRESS IN ORGANIC COATINGS,201,13. |
| MLA | Qi, Shiqian,et al."Unveiling the effect of bovine serum albumin on the packaging performance of medical silicone rubber coating for implantable electronic devices".PROGRESS IN ORGANIC COATINGS 201(2025):13. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。