Triterpenoids and Steroids with Cytotoxic Activity from Emmenopterys henryi
文献类型：期刊论文
| 作者 | Wu, Xing-De1; He, Juan1; Li, Xing-Yao1; Dong, Liao-Bin1; Gong, Xun1 ; Gao, Xiu1; Song, Liu-Dong2,3; Li, Yan1; Peng, Li-Yan1; Zhao, Qin-Shi1
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| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2013-09-01 |
| 卷号 | 79期号:14页码:1356-1361 |
| ISSN号 | 0032-0943 |
| 关键词 | Emmenopterys henryi Rubiaceae ursane-type triterpenoids pregnane derivatives cytotoxic activity |
| 通讯作者 | Zhao, QS (reprint author), State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China.,ynsld@126.com |
| 英文摘要 | Two new ursane-type triterpenoids, 3,19,23-trihydroxyurs-12-en-24-al-28-oic acid (1) and 3,19,24-trihydroxy-23-norurs-12-en-28-oic acid (2), two new pregnane derivatives, 3,12-dihydroxy-5-pregnane-14,16-dien-20-one (9) and 12-hydroxy-5-pregnane-14,16-dien-3,20-dione (10), and eight known compounds were isolated from the twigs and leaves of Emmenopterys henryi. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 4, 11, and 12 showed cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines with IC50 values in the range of 3.11-20.12 mu M. |
| 学科主题 | Plant Sciences ; Chemistry ; Medicinal ; Pharmacology & Pharmacy |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | ACIDS |
| 资助信息 | National Basic Research Program of China (973 Program) [2009CB522303, 2011CB915503]; National Natural Science Foundation of China [90813004, U0932602]; Chinese Academy of Sciences [2009311211011, 2009312311024] |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000324892000011 |
| 公开日期 | 2013-11-12 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/17286]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China 3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Xing-De,He, Juan,Li, Xing-Yao,et al. Triterpenoids and Steroids with Cytotoxic Activity from Emmenopterys henryi[J]. PLANTA MEDICA,2013,79(14):1356-1361. |
| APA | Wu, Xing-De.,He, Juan.,Li, Xing-Yao.,Dong, Liao-Bin.,Gong, Xun.,...&Zhao, Qin-Shi.(2013).Triterpenoids and Steroids with Cytotoxic Activity from Emmenopterys henryi.PLANTA MEDICA,79(14),1356-1361. |
| MLA | Wu, Xing-De,et al."Triterpenoids and Steroids with Cytotoxic Activity from Emmenopterys henryi".PLANTA MEDICA 79.14(2013):1356-1361. |
入库方式： OAI收割
来源：昆明植物研究所
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