Identification of two novel inhibitors of mTOR signaling pathway based on high content screening
文献类型：期刊论文
| 作者 | Yan, Juming1,2; Zhou, Hongyu1; Kong, Lingmei1,2; Zhang, Jing1,2; Zhao, Qinshi1 ; Li, Yan1
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| 刊名 | CANCER CHEMOTHERAPY AND PHARMACOLOGY
 |
| 出版日期 | 2013-10-01 |
| 卷号 | 72期号:4页码:799-808 |
| 关键词 | mTOR signaling Inhibitor High content screening Cancer Apoptosis |
| ISSN号 | 0344-5704 |
| 通讯作者 | Li, Y (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China.,liyanb@mail.kib.ac.cn |
| 英文摘要 | Mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation and survival. Dysregulation of mTOR signaling pathway is closely involved in cancer development and chemotherapy resistance. Inhibitors of mTOR signaling pathway have been demonstrated to be attractive therapeutics for cancer therapy. In the present study, we aim to discover novel mTOR signaling pathway inhibitors from a natural compound library. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | Oncology ; Pharmacology & Pharmacy |
| 类目[WOS] | Oncology ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Oncology ; Pharmacology & Pharmacy |
| 关键词[WOS] | CANCER-THERAPY ; ANTICANCER THERAPY ; MAMMALIAN TARGET ; RNA REGULON ; EIF4E ; TRANSLATION ; PHOSPHORYLATION ; COMPLEX ; GROWTH ; CYTOSKELETON |
| 收录类别 | SCI |
| 资助信息 | hundreds of talents program; west light foundation of the Chinese Academy of Sciences; Major State Basic Research Development Program of China [2009CB522300]; NSFC [81173076]; project of recruited top talent of science and technology of Yunnan Province [2009C1120] |
| 语种 | 英语 |
| WOS记录号 | WOS:000324879100009 |
| 公开日期 | 2013-11-12 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/17289]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Juming,Zhou, Hongyu,Kong, Lingmei,et al. Identification of two novel inhibitors of mTOR signaling pathway based on high content screening[J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY,2013,72(4):799-808. |
| APA | Yan, Juming,Zhou, Hongyu,Kong, Lingmei,Zhang, Jing,Zhao, Qinshi,&Li, Yan.(2013).Identification of two novel inhibitors of mTOR signaling pathway based on high content screening.CANCER CHEMOTHERAPY AND PHARMACOLOGY,72(4),799-808. |
| MLA | Yan, Juming,et al."Identification of two novel inhibitors of mTOR signaling pathway based on high content screening".CANCER CHEMOTHERAPY AND PHARMACOLOGY 72.4(2013):799-808. |
入库方式： OAI收割
来源：昆明植物研究所
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