Gastric Cancer Models Developed via GelMA 3D Bioprinting Accurately Mimic Cancer Hallmarks, Tumor Microenvironment Features, and Drug Responses
文献类型：期刊论文
| 作者 | Ju, Mingguang1; Jin, Zhizhong2; Yu, Xue1; Huang, Caihao3; Li, Yanshu4,5; Gao, Ziming1; Li, He1; Huang, Haibo1; Zheng, Chen1; Jia, Shiheng1 |
| 刊名 | SMALL
 |
| 出版日期 | 2025-01-15 |
| 页码 | 20 |
| 关键词 | 3D bioprinting 3D Cultures Gastric Cancer GelMA Tumor Models |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.202409321 |
| 通讯作者 | Zhou, Heng(hzhou@cmu.edu.cn) ; Zhang, Xing(xingzhang@imr.ac.cn) ; Li, Kai(kli@cmu.edu.cn) |
| 英文摘要 | Current in vitro models for gastric cancer research, such as 2D cell cultures and organoid systems, often fail to replicate the complex extracellular matrix (ECM) found in vivo. For the first time, this study utilizes a gelatin methacryloyl (GelMA) hydrogel, a biomimetic ECM-like material, in 3D bioprinting to construct a physiologically relevant gastric cancer model. GelMA's tunable mechanical properties allow for the precise manipulation of cellular behavior within physiological ranges. Genetic and phenotypic analyses indicate that the 3D bioprinted GelMA (3Db) model accurately mimics the clinical tumor characteristics and reproduces key cancer hallmarks, such as cell proliferation, invasion, migration, angiogenesis, and the Warburg effect. Comparisons of gene expression and drug responses between the 3Db model and patient-derived xenograft models, both constructed from primary gastric cancer cells, validate the model's clinical relevance. The ability of the 3Db model to closely simulate in vivo conditions highlights its crucial role in identifying treatment targets and predicting patient-specific responses, showcasing its potential in high-throughput drug screening and clinical applications. This study is the first to report the pivotal role of GelMA-based 3D bioprinting in advancing gastric cancer research and regenerative medicine. |
| 资助项目 | Key Research and Development Program of Liaoning Province[2023YFC2413702] ; National Key R&D Program of China ; Ministry of Science and Technology of the People's Republic of China[2023JH2/101700105] ; Liaoning Provincial Science and Technology Joint Program |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001396733000001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | Key Research and Development Program of Liaoning Province ; National Key R&D Program of China ; Ministry of Science and Technology of the People's Republic of China ; Liaoning Provincial Science and Technology Joint Program |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Zhou, Heng; Zhang, Xing; Li, Kai |
| 作者单位 | 1.China Med Univ, Dept Surg Oncol & Gen Surg, Key Lab Precis Diag & Treatment Gastrointestinal T, Minist Educ,Affiliated Hosp 1, Shenyang 110001, Peoples R China 2.China Med Univ, Dept Neurosurg, Affiliated Hosp 1, Shenyang 110001, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 4.China Med Univ, Dept Cell Biol, Key Lab Cell Biol, Natl Hlth Commiss PRC,Minist Educ PRC, Shenyang 110122, Peoples R China 5.China Med Univ, Key Lab Med Cell Biol, Minist Educ PRC, Shenyang 110122, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ju, Mingguang,Jin, Zhizhong,Yu, Xue,et al. Gastric Cancer Models Developed via GelMA 3D Bioprinting Accurately Mimic Cancer Hallmarks, Tumor Microenvironment Features, and Drug Responses[J]. SMALL,2025:20. |
| APA | Ju, Mingguang.,Jin, Zhizhong.,Yu, Xue.,Huang, Caihao.,Li, Yanshu.,...&Li, Kai.(2025).Gastric Cancer Models Developed via GelMA 3D Bioprinting Accurately Mimic Cancer Hallmarks, Tumor Microenvironment Features, and Drug Responses.SMALL,20. |
| MLA | Ju, Mingguang,et al."Gastric Cancer Models Developed via GelMA 3D Bioprinting Accurately Mimic Cancer Hallmarks, Tumor Microenvironment Features, and Drug Responses".SMALL (2025):20. |
入库方式： OAI收割
来源：金属研究所
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