Optimization of the in vitro biodegradability, cytocompatibility, and wear resistance of the AZ31B alloy by micro-arc oxidation coatings doped with zinc phosphate
文献类型：期刊论文
| 作者 | Yang, Chao1,8,9; Cui, Suihan1,2,3; Fu, Ricky K. Y.3; Sheng, Liyuan4,5; Wen, Min4; Xu, Daokui6; Zhao, Ying7; Zheng, Yufeng4; Chu, Paul K.2,3; Wu, Zhongzhen1 |
| 刊名 | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2024-04-20 |
| 卷号 | 179页码:224-239 |
| 关键词 | Mg alloys MAO coatings Degradation regulation Cytocompatibility Wear resistance |
| ISSN号 | 1005-0302 |
| DOI | 10.1016/jamst.2023.09.019 |
| 通讯作者 | Cui, Suihan(cuish@pku.edu.cn) ; Sheng, Liyuan(lysheng@yeah.net) ; Wu, Zhongzhen(wuzz@pkusz.edu.cn) |
| 英文摘要 | As implanted bone fixation materials, magnesium (Mg) alloys have significant advantages because the density and elastic modulus are closest to those of the human bone and they can bio-degrade in the physiological environment. However, Mg alloys degrade too rapidly and uncontrollably thus hampering clinical adoption. In this study, a highly corrosion-resistant zinc-phosphate-doped micro-arc oxidation (MAO) coating is prepared on the AZ31B alloy, and the degradation process is assessed in vitro. With increasing zinc phosphate concentrations, both the corrosion potentials and charge transfer resistance of the AZ31B alloy coated with MAO coatings increase gradually, while the corrosion current densities di-minish gradually. Immersion tests in the simulated body fluid (SBF) reveal that the increased zinc phos-phate concentration in MAO coating decreases the degradation rate, consequently reducing the release rates of Mg2+ and OH - in the physiological micro-environment, which obtains the lowest weight loss of only 5.22% after immersion for 56 days. Effective regulation of degradation provides a weak alkaline environment that is suitable for long-term cell growth and subsequent promotion of bone proliferation, differentiation, mineralization, and cytocompatibility. In addition, the zinc-phosphate-doped MAO coat-ings show an improved wear resistance as manifested by a wear rate of only 3.81 x 10 -5 mm3 N -1 m -1 . The results reveal a suitable strategy to improve the properties of biodegradable Mg alloys to balance tissue healing with mechanical degradation.(c) 2023 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology. |
| 资助项目 | Shenzhen-Hong Kong Research and Development Fund[SGDX20201103095406024] ; 2022 Shenzhen Sustainable Supporting Funds for Colleges and Universities[20220810143642004] ; Shenzhen Basic Research Project[JCYJ20200109144608205] ; Shenzhen Basic Research Project[JCYJ20210324120001003] ; Guangdong Basic and Applied Basic Research Foundation[2020A1515011301] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515012246] ; Peking University Shenzhen Graduate School Research Start-up Fund of Introducing Talent[1270110273] ; Shenzhen Postdoctoral Research Fund Project after Outbound[2129933651] ; China Postdoctoral Science Foundation[2023M730032] ; City University of Hong Kong Strategic Research Grants (SRG)[7005505] ; City University of Hong Kong Donation Research Grants[9220061] ; City University of Hong Kong Donation Research Grants[9229021] ; Guangdong-Hong Kong Technology Cooperation Funding Scheme (TCFS)[GHP/085/18SZ] ; Shenzhen-Hong Kong Technology Cooperation Funding Scheme (TCFS)[GHP/149/20SZ] ; Shenzhen-Hong Kong Technology Cooperation Funding Scheme (TCFS)[CityU 9440296] ; IER Foundation[IERF2020001] ; IER Foundation[IERF202102] |
| WOS研究方向 | Materials Science ; Metallurgy & Metallurgical Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001124223100001 |
| 出版者 | JOURNAL MATER SCI TECHNOL |
| 资助机构 | Shenzhen-Hong Kong Research and Development Fund ; 2022 Shenzhen Sustainable Supporting Funds for Colleges and Universities ; Shenzhen Basic Research Project ; Guangdong Basic and Applied Basic Research Foundation ; Peking University Shenzhen Graduate School Research Start-up Fund of Introducing Talent ; Shenzhen Postdoctoral Research Fund Project after Outbound ; China Postdoctoral Science Foundation ; City University of Hong Kong Strategic Research Grants (SRG) ; City University of Hong Kong Donation Research Grants ; Guangdong-Hong Kong Technology Cooperation Funding Scheme (TCFS) ; Shenzhen-Hong Kong Technology Cooperation Funding Scheme (TCFS) ; IER Foundation |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Cui, Suihan; Sheng, Liyuan; Wu, Zhongzhen |
| 作者单位 | 1.Peking Univ, Sch Adv Mat, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China 2.City Univ Hong Kong, Dept Phys, Dept Mat Sci & Engn, Kowloon, Tat Chee Ave, Hong Kong 999077, Peoples R China 3.City Univ Hong Kong, Dept Biomed Engn, Kowloon, Tat Chee Ave, Hong Kong 999077, Peoples R China 4.Peking Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China 5.PKU HKUST Shenzhen Hong Kong Inst, Shenzhen 518057, Peoples R China 6.Chinese Acad Sci, Key Lab Nucl Mat & Safety Assessment, Inst Met Res, Shenyang 110016, Peoples R China 7.Shenzhen Inst Adv Technol, Chinese Acad Sci, Shenzhen 518055, Peoples R China 8.Shanghai Jiao Tong Univ, Natl Engn Res Ctr Light Alloy Net Forming, Shanghai 200240, Peoples R China 9.Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composite, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Chao,Cui, Suihan,Fu, Ricky K. Y.,et al. Optimization of the in vitro biodegradability, cytocompatibility, and wear resistance of the AZ31B alloy by micro-arc oxidation coatings doped with zinc phosphate[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2024,179:224-239. |
| APA | Yang, Chao.,Cui, Suihan.,Fu, Ricky K. Y..,Sheng, Liyuan.,Wen, Min.,...&Wu, Zhongzhen.(2024).Optimization of the in vitro biodegradability, cytocompatibility, and wear resistance of the AZ31B alloy by micro-arc oxidation coatings doped with zinc phosphate.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,179,224-239. |
| MLA | Yang, Chao,et al."Optimization of the in vitro biodegradability, cytocompatibility, and wear resistance of the AZ31B alloy by micro-arc oxidation coatings doped with zinc phosphate".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 179(2024):224-239. |
入库方式： OAI收割
来源：金属研究所
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