Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis
文献类型：期刊论文
| 作者 | Liu, Leyi1,2; Wu, Jie1,2; Lv, Shiyu1,2; Xu, Duoling1,2; Li, Shujun3; Hou, Wentao3; Wang, Chao1,2; Yu, Dongsheng1,2 |
| 刊名 | MATERIALS TODAY BIO
 |
| 出版日期 | 2023-12-01 |
| 卷号 | 23页码:19 |
| 关键词 | Hierarchical topography UiO-66 Coupling of osteogenesis and angiogenesis |
| ISSN号 | 2590-0064 |
| DOI | 10.1016/j.mtbio.2023.100866 |
| 通讯作者 | Wang, Chao(wangch373@mail.sysu.edu.cn) ; Yu, Dongsheng(yudsh@mail.sysu.edu.cn) |
| 英文摘要 | The significance of the osteogenesis-angiogenesis relationship in the healing process of bone defects has been increasingly emphasized in recent academic research. Surface topography plays a crucial role in guiding cellular behaviors. Metal-organic framework (MOF) is an innovative biomaterial with nanoscale structural and topological features, enabling the modulation of scaffold physicochemical properties. This study involved the loading of varying quantities of UiO-66 nanocrystals onto alkali-heat treated 3D-printed titanium scaffolds, resulting in the formation of hierarchical micro/nano topography named UiO-66/AHTs. The physicochemical properties of these scaffolds were subsequently characterized. Furthermore, the impact of these scaffolds on the osteogenic potential of BMSCs, the angiogenic potential of HUVECs, and their intercellular communication were investigated. The findings of this study indicated that 1/2UiO-66/AHT outperformed other groups in terms of osteogenic and angiogenic induction, as well as in promoting intercellular crosstalk by enhancing paracrine effects. These results suggest a promising biomimetic hierarchical topography design that facilitates the coupling of osteogenesis and angiogenesis. |
| 资助项目 | National Natural Science Foundation of China[82073378] ; National Natural Science Foundation of China[81974146] ; Natural Science Foundation of Guangdong Province[2021A1515012399] ; Shenyang Talents program[RC200230] ; Special Funds for the Cultivation of Guangdong College Students ' Scientific and Technological Innovation ( Climbing Program Special Funds)[pdjh2022b0012] ; Special Funds for the Cultivation of Guangdong College Students ' Scientific and Technological Innovation ( Climbing Program Special Funds)[pdjh2023a0004] ; National Undergraduate Training Program for Innovation and Entrepreneurship[202310824] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001135416900001 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Shenyang Talents program ; Special Funds for the Cultivation of Guangdong College Students ' Scientific and Technological Innovation ( Climbing Program Special Funds) ; National Undergraduate Training Program for Innovation and Entrepreneurship |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Wang, Chao; Yu, Dongsheng |
| 作者单位 | 1.Sun Yat Sen Univ, Hosp Stomatol, Guangzhou 510055, Peoples R China 2.Sun Yat Sen Univ, Guanghua Sch Stomatol, Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Leyi,Wu, Jie,Lv, Shiyu,et al. Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis[J]. MATERIALS TODAY BIO,2023,23:19. |
| APA | Liu, Leyi.,Wu, Jie.,Lv, Shiyu.,Xu, Duoling.,Li, Shujun.,...&Yu, Dongsheng.(2023).Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis.MATERIALS TODAY BIO,23,19. |
| MLA | Liu, Leyi,et al."Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis".MATERIALS TODAY BIO 23(2023):19. |
入库方式： OAI收割
来源：金属研究所
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