Physically cross-linked chitosan gel with tunable mechanics and biodegradability for tissue engineering scaffold
文献类型：期刊论文
| 作者 | Pan, Peng1,2; Wang, Jian3; Wang, Xi4; Kang, Ye5; Yu, Xinding; Chen, Tiantian1,2; Hao, Yulin1,2; Liu, Wentao1,2 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2024-02-01 |
| 卷号 | 257页码:12 |
| 关键词 | Physical chitosan gel Water content Tissue engineering scaffold |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2023.128682 |
| 通讯作者 | Liu, Wentao(wtliu@imr.ac.cn) |
| 英文摘要 | Chitosan, a cationic polysaccharide, exhibits promising potential for tissue engineering applications. However, the poor mechanical properties and rapid biodegradation have been the major limitations for its applications. In this work, an effective strategy was proposed to optimize the mechanical performance and degradation rate of chitosan gel scaffolds by regulating the water content. Physical chitosan hydrogel (HG, with 93.57 % water) was prepared by temperature-controlled cross-linking, followed by dehydration to obtain xerogel (XG, with 2.84 % water) and rehydration to produce wet gel (WG, with 56.06 % water). During this process, changes of water content significantly influenced the water existence state, hydrogen bonding, and the chain entanglements of chitosan in the gel network. The mechanical compression results showed that the chitosan gel scaffolds exhibited tunable compressive strength (0.3128-139 MPa) and compressive modulus (0.2408-1094 MPa). XG could support weights exceeding 65,000 times its own mass while maintaining structural stability. Furthermore, in vitro and in vivo experiments demonstrated that XG and WG exhibited better biocompatibility and resistance to biodegradation compared with HG. Overall, this work contributes to the design and optimization of chitosan scaffolds without additional chemical crosslinkers, which has potential in tissue engineering and further clinical translation. |
| 资助项目 | Natural Science Foundation of Liaoning Province[2022-YGJC-02] ; Applied Basic Research Programs of Liaoning Province[2022JH2/101300104] ; Young Talents Project of Shenyang National Laboratory for Materials Science[E01SL607] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001137763900001 |
| 出版者 | ELSEVIER |
| 资助机构 | Natural Science Foundation of Liaoning Province ; Applied Basic Research Programs of Liaoning Province ; Young Talents Project of Shenyang National Laboratory for Materials Science |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Liu, Wentao |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China 3.Jinzhou Med Univ, Dept Orthoped, Affiliated Hosp 1, Jinzhou 121000, Peoples R China 4.China Med Univ, Sch & Hosp Stomatol, Dept Emergency & Oral Med, Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Peoples R China 5.China Med Univ, Dept Pathol, Shengjing Hosp, Shenyang 110004, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, Peng,Wang, Jian,Wang, Xi,et al. Physically cross-linked chitosan gel with tunable mechanics and biodegradability for tissue engineering scaffold[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,257:12. |
| APA | Pan, Peng.,Wang, Jian.,Wang, Xi.,Kang, Ye.,Yu, Xinding.,...&Liu, Wentao.(2024).Physically cross-linked chitosan gel with tunable mechanics and biodegradability for tissue engineering scaffold.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,257,12. |
| MLA | Pan, Peng,et al."Physically cross-linked chitosan gel with tunable mechanics and biodegradability for tissue engineering scaffold".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 257(2024):12. |
入库方式： OAI收割
来源：金属研究所
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