In vivo biodegradation and biological properties of a Mg-Zn-Ca amorphous alloy for bone defect repair
文献类型：期刊论文
| 作者 | Meng, J.1; Zhang, Y.2; Yu, X.3; Jiao, J.4; Tan, L.5,7; Yu, B.6,8 |
| 刊名 | MATERIALS TECHNOLOGY
 |
| 出版日期 | 2024-12-31 |
| 卷号 | 39期号:1页码:19 |
| 关键词 | Mg-Zn-Ca amorphous alloy bone defects biodegradation osteogenesis |
| ISSN号 | 1066-7857 |
| DOI | 10.1080/10667857.2024.2307846 |
| 通讯作者 | Tan, L.(lltan@imr.ac.cn) ; Yu, B.(71000322@sdutcm.edu.cn) |
| 英文摘要 | Amorphous magnesium alloys, characterised by their unique disordered structure, exhibit exceptional mechanical properties and superior corrosion resistance. This study introduced a novel biodegradable Mg-Zn-Ca amorphous alloy. Immersion and electrochemical tests revealed uniform degradation in a simulated body fluid environment. The degradation products predominantly contained zinc and oxygen. After 28 days of immersion, the alloy's structure largely remained intact, and it exhibited a minimal weight loss rate of 11.64 +/- 1.85%, indicating its excellent corrosion resistance. In addition, the homogeneous and rapid degradation of the Mg-Zn-Ca amorphous alloy in rats (the residual volume at 12 weeks was 14.94 +/- 5.05%, at least 2-3 times of the corrosion rate of immersion in vitro), thus increasing the bone volume/total volume and trabecular number. The new bone and the residual material surface showed good bone integration. Blood and organ tissue tests confirmed the in vivo biological safety. Therefore, Mg-Zn-Ca amorphous alloys have excellent potential as bone-repair materials, especially in load-bearing areas. |
| 资助项目 | National Natural Science Foundation of China[51971222] ; Natural Science Foundation of Shandong Province[ZR2022MH021] ; Clinical Medical Science and Technology Innovation Program of the Jinan Science and Technology Bureau[202019156] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001154203400001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province ; Clinical Medical Science and Technology Innovation Program of the Jinan Science and Technology Bureau |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Tan, L.; Yu, B. |
| 作者单位 | 1.Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan, Peoples R China 2.Nanjing Univ Sci & Technol, Nano & Heterogeneous Mat Ctr, Sch Mat Sci & Engn, Nanjing, Peoples R China 3.Shanghai Univ, Sch Mat Sci & Engn, Shanghai, Peoples R China 4.Shanghai Univ Med & Hlth Sci, Dept Orthoped, Jiading Dist Cent Hosp, Shanghai, Peoples R China 5.Chinese Acad Sci, Inst Met Res, Shenyang, Peoples R China 6.Shandong Univ Tradit Chinese Med, Dept Orthopaed, Affiliated Hosp, Jinan, Peoples R China 7.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 8.Shandong Univ Tradit Chinese Med, Dept Orthopaed, Affiliated Hosp, Jinan 250014, Peoples R China |
| 推荐引用方式 GB/T 7714 | Meng, J.,Zhang, Y.,Yu, X.,et al. In vivo biodegradation and biological properties of a Mg-Zn-Ca amorphous alloy for bone defect repair[J]. MATERIALS TECHNOLOGY,2024,39(1):19. |
| APA | Meng, J.,Zhang, Y.,Yu, X.,Jiao, J.,Tan, L.,&Yu, B..(2024).In vivo biodegradation and biological properties of a Mg-Zn-Ca amorphous alloy for bone defect repair.MATERIALS TECHNOLOGY,39(1),19. |
| MLA | Meng, J.,et al."In vivo biodegradation and biological properties of a Mg-Zn-Ca amorphous alloy for bone defect repair".MATERIALS TECHNOLOGY 39.1(2024):19. |
入库方式： OAI收割
来源：金属研究所
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