Improving osteoinduction and osteogenesis of Ti6Al4V alloy porous scaffold by regulating the pore structure
文献类型：期刊论文
| 作者 | Wang, Chao1,2; Wu, Jie1,2; Liu, Leyi1,2; Xu, Duoling1,2; Liu, Yuanbo1,2; Li, Shujun3; Hou, Wentao3; Wang, Jian4; Chen, Xun1,2; Sheng, Liyuan4 |
| 刊名 | FRONTIERS IN CHEMISTRY
 |
| 出版日期 | 2023-05-17 |
| 卷号 | 11页码:15 |
| 关键词 | porous scaffold Ti6Al4V alloy pore structure osteogenesis bone defect repairing |
| ISSN号 | 2296-2646 |
| DOI | 10.3389/fchem.2023.1190630 |
| 通讯作者 | Sheng, Liyuan(lysheng@yeah.net) ; Lin, Huancai(linhc@mail.sysu.edu.cn) ; Yu, Dongsheng(yudsh@mail.sysu.edu.cn) |
| 英文摘要 | Titanium alloy scaffolds with a porous structure have attracted much attention in bone defect repair. However, which pore structure is more beneficial to bone defect repair is controversial. In the present research, the Ti6Al4V alloy porous scaffolds with gradient pore sizes were designed and fabricated. The microstructure characterization, tests of mechanical properties, and in vitro and in vivo experiments have been performed to systematically evaluate the effect of pore size on osteoinduction and osteogenesis. The results revealed that the contact angle with water, compressive strength, and elastic modulus of the Ti6Al4V alloy porous scaffolds decreased gradually with the increase of pore size. However, there were obvious drops when the pore size of the porous scaffold was around 600 mu m. As the pore size increased, the proliferation and integrin beta 1 of RAW 264.7 macrophages seeded on Ti6Al4V alloy porous scaffolds increased at first, reaching a maximum value at a pore size of around 600 mu m, and then decreased subsequently. The proliferation, integrin beta 1, and osteogenic gene-related expressions of Bone marrow mesenchymal stem cells (BMSCs) seeded on Ti6Al4V alloy porous scaffolds with different pore sizes all exhibited similar variations which rose with increased pore size firstly, obtaining the maximum value at pore size about 600 mu m, and then declined. The in vivo experiments confirmed the in vitro results, and the Ti6Al4V alloy porous scaffold with a pore size of 600 mu m possessed the better capability to induce new bone formation. Therefore, for the design of Ti6Al4V alloy with a regular porous scaffold, the surface morphology, porosity, strength, and elastic modulus should be considered systematically, which would determine the capability of osteoinduction and osteogenesis. |
| 资助项目 | National Natural Science Foundation of China[81974146] ; National Natural Science Foundation of China[U2241245] ; National Natural Science Foundation of China[51871220] ; Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation[pdjh 2022b0012] ; Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation[pdjh 2023a0004] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001159067000001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China ; Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation |
| 源URL |  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Sheng, Liyuan; Lin, Huancai; Yu, Dongsheng |
| 作者单位 | 1.Sun Yat Sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, Guangzhou, Peoples R China 2.Sun Yat Sen Univ, Guangdong Prov Key Lab Stomatol, Guangzhou, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang, Peoples R China 4.Peking Univ, Shenzhen Inst, Shenzhen, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Chao,Wu, Jie,Liu, Leyi,et al. Improving osteoinduction and osteogenesis of Ti6Al4V alloy porous scaffold by regulating the pore structure[J]. FRONTIERS IN CHEMISTRY,2023,11:15. |
| APA | Wang, Chao.,Wu, Jie.,Liu, Leyi.,Xu, Duoling.,Liu, Yuanbo.,...&Yu, Dongsheng.(2023).Improving osteoinduction and osteogenesis of Ti6Al4V alloy porous scaffold by regulating the pore structure.FRONTIERS IN CHEMISTRY,11,15. |
| MLA | Wang, Chao,et al."Improving osteoinduction and osteogenesis of Ti6Al4V alloy porous scaffold by regulating the pore structure".FRONTIERS IN CHEMISTRY 11(2023):15. |
入库方式： OAI收割
来源：金属研究所
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